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Complex heritability in cardiomyopathy

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Human cardiomyocytes and mice edited to harbour gene variants found in patients with dilated cardiomyopathy reveal combinatorial genetic interactions that contribute to the complex genetic heritability of the disease.

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Fig. 1: Genome-edited cardiomyocytes and mouse models for studying the genetic basis of cardiovascular diseases.

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Authors and Affiliations

  1. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA

    Ning Ma, Sophia L. Zhang & Joseph C. Wu

  2. Division of Cardiology, Department of Medicine, Stanford University, Stanford, CA, USA

    Ning Ma, Sophia L. Zhang & Joseph C. Wu

  3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Ning Ma, Sophia L. Zhang & Joseph C. Wu

Authors
  1. Ning Ma
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  2. Sophia L. Zhang
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  3. Joseph C. Wu
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Correspondence to Joseph C. Wu.

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Ma, N., Zhang, S.L. & Wu, J.C. Complex heritability in cardiomyopathy. Nat Biomed Eng 3, 87–89 (2019). https://doi.org/10.1038/s41551-019-0353-z

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