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Patient-derived co-cultures for studying ALS

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Co-cultures of muscle cells and optogenetic motor neurons derived from patient-specific human stem cells make a physiologically relevant model of amyotrophic lateral sclerosis.

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Fig. 1: Microphysiological 3D co-culture of motor neurons and skeletal muscles derived from human stem cells for the modelling of ALS.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Ariel Ionescu & Eran Perlson

  2. Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel

    Ariel Ionescu & Eran Perlson

Authors
  1. Ariel Ionescu
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  2. Eran Perlson
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Correspondence to Eran Perlson.

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Ionescu, A., Perlson, E. Patient-derived co-cultures for studying ALS. Nat Biomed Eng 3, 13–14 (2019). https://doi.org/10.1038/s41551-018-0333-8

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