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CANCER IMMUNOTHERAPY

Combined local and systemic attacks

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Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade, inhibits tumour growth in mouse models of localized cancer and metastatic cancer.

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Fig. 1: Mechanisms supporting the antitumour immune responses induced by 131I-Cat/CpG/ALG-based radioimmunotherapy in combination with immune checkpoint blockade.

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Authors and Affiliations

  1. Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA

    Catherine S. Spina

  2. Department of Medicine, Division of Hematology / Oncology, Columbia University Medical Center, New York, NY, USA

    Charles G. Drake

  3. Department of Urology, Columbia University Medical Center, New York, NY, USA

    Charles G. Drake

Authors
  1. Catherine S. Spina
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  2. Charles G. Drake
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Correspondence to Charles G. Drake.

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Spina, C.S., Drake, C.G. Combined local and systemic attacks. Nat Biomed Eng 2, 564–565 (2018). https://doi.org/10.1038/s41551-018-0277-z

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