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Heart repair via cardiomyocyte-secreted vesicles

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The sustained delivery of extracellular vesicles, secreted by induced-pluripotent-stem-cell-derived cardiomyocytes, through a hydrogel patch promotes cardiac recovery after myocardial infarction in rats.

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Fig. 1: The delivery of cardiac-derived extracellular vesicles via a hydrogel patch enhances heart repair.

References

  1. Cambria, E. et al. npj Regen. Med. 2, 17 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tzahor, E. & Poss, K. D. Science 356, 1035–1039 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Kim, S. M. & Kim, H. S. Stem Cell Invest. 4, 74 (2017).

    Article  CAS  Google Scholar 

  4. van Niel, G., D'Angelo, G. & Raposo, G. Nat. Rev. Mol. Cell Biol. 19, 213–228 (2018).

    Article  PubMed  CAS  Google Scholar 

  5. Gallet, R. et al. Eur. Heart J. 38, 201–211 (2017).

    PubMed  Google Scholar 

  6. Khan, M. et al. Circ. Res. 117, 52–64 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Bian, S. et al. J. Mol. Med. 92, 387–397 (2014).

    Article  PubMed  CAS  Google Scholar 

  8. Mackie, A. R. et al. Circ. Res. 111, 312–321 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Wallace, D. G. & Rosenblatt, J. Adv. Drug Del. Rev. 55, 1631–1649 (2003).

    Article  CAS  Google Scholar 

  10. Taylor, D. A., Sampaio, L. C. & Gobin, A. Am. J. Transplant. 14, 2448–2459 (2014).

    Article  PubMed  CAS  Google Scholar 

  11. Liu, B. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0229-7 (2018).

  12. Wang, L. L. et al. Nat. Biomed. Eng. 1, 983–992 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX, USA

    Todd R. Heallen & James F. Martin

  2. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA

    James F. Martin

Authors
  1. Todd R. Heallen
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  2. James F. Martin
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Correspondence to James F. Martin.

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Heallen, T.R., Martin, J.F. Heart repair via cardiomyocyte-secreted vesicles. Nat Biomed Eng 2, 271–272 (2018). https://doi.org/10.1038/s41551-018-0239-5

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