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GENOME EDITING

Nanoparticles for CRISPR–Cas9 delivery

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The DNA mutation that causes Duchenne muscular dystrophy in mice can be corrected, with minimal off-target effects, by gold nanoparticles carrying the CRISPR components.

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Fig. 1: Genome editing via nanoparticle-mediated delivery of the CRISPR–Cas9 machinery.

References

  1. Hsu, P.  D., Lander, E.  S. & Zhang, F. Cell 157, 1262–1278 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Doudna, J.  A. & Charpentier, E. Science 346, 1258096 (2014).

    Article  PubMed  Google Scholar 

  3. Tabebordbar, M. et al. Science 351, 407–411 (2016).

    Article  CAS  PubMed  Google Scholar 

  4. Nelson, C.  E. et al. Science 351, 403–407 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Long, C. et al. Science 351, 400–403 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Lee, K. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-017-0137-2 (2017).

  7. Ramadasan-Nair, R. et al. J. Biol. Chem. 289, 485–509 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Wang, M., Glass, Z.  A. & Xu, Q. Gene Ther. 24, 144–150 (2017).

    Article  CAS  PubMed  Google Scholar 

  9. Wang, H.-X. et al. Chem. Rev. 117, 9874–9906 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Yin, H., Kauffman, K.  J. & Anderson, D.  G. Nat. Rev. Drug Discov. 16, 387–399 (2017).

    Article  CAS  PubMed  Google Scholar 

  11. Staahl, B.  T. et al. Nat. Biotechnol. 35, 431–434 (2017).

    Article  CAS  PubMed  Google Scholar 

  12. Zuris, J.  A. et al. Nat. Biotechnol. 33, 73–80 (2015).

    Article  CAS  PubMed  Google Scholar 

  13. Wang, M. et al. Proc. Natl Acad. Sci. USA 113, 2868–2873 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ran, F. A. et al. Nat. Protoc 8, 2281–2308 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Engineering, Tufts University, Medford, MA, USA

    Zachary Glass, Yamin Li & Qiaobing Xu

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  1. Zachary Glass
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  2. Yamin Li
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  3. Qiaobing Xu
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Correspondence to Qiaobing Xu.

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Glass, Z., Li, Y. & Xu, Q. Nanoparticles for CRISPR–Cas9 delivery. Nat Biomed Eng 1, 854–855 (2017). https://doi.org/10.1038/s41551-017-0158-x

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