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Cancer immunotherapy: Wound-bound checkpoint blockade

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Platelets delivering the immunotherapeutic antibody anti-PD-L1 to the site of surgically removed tumours reduce cancer recurrence and metastatic spread in mice.

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Figure 1: Clinically approved immune checkpoint inhibitors.
Figure 2: Platelet-mediated delivery of anti-PD-L1 to surgical wound sites.

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Correspondence to Morteza Mahmoudi or Omid C. Farokhzad.

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Mahmoudi, M., Farokhzad, O. Cancer immunotherapy: Wound-bound checkpoint blockade. Nat Biomed Eng 1, 0031 (2017). https://doi.org/10.1038/s41551-017-0031

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