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Synthetic gene circuits: Insulin self-regulation

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A self-adjusting synthetic gene circuit senses and reverses insulin resistance in animal models of diabetes and obesity.

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Figure 1: Insulin-sensitizing synthetic gene circuit for the secretion of adiponectin.

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Authors and Affiliations

  1. Nobuhiro Shojima and Takashi Kadowaki are in the Department of Diabetes and Metabolic Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.,

    Nobuhiro Shojima & Takashi Kadowaki

Authors
  1. Nobuhiro Shojima
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  2. Takashi Kadowaki
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Correspondence to Takashi Kadowaki.

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Shojima, N., Kadowaki, T. Synthetic gene circuits: Insulin self-regulation. Nat Biomed Eng 1, 0020 (2017). https://doi.org/10.1038/s41551-016-0020

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  • DOI: https://doi.org/10.1038/s41551-016-0020

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