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Drug delivery: Brushing off antigenicity

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Conjugation of a diabetes drug with a brush polymer reduces the reactivity of the drug conjugate towards pre-existing polymer antibodies in human plasma and improves the drug's performance in diabetic mice.

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Figure 1: A PEGylation approach for improving drug half-life and eliminating PEG antigenicity.

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Authors and Affiliations

  1. Kang Choon Lee is at the School of Pharmacy, Sungkyunkwan University, Suwon 16469, Korea.,

    Kang Choon Lee

  2. Seulki Lee is at The Russell H. Morgan Department of Radiology and Radiological Sciences and The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.,

    Seulki Lee

Authors
  1. Kang Choon Lee
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  2. Seulki Lee
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Correspondence to Kang Choon Lee or Seulki Lee.

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Lee, K., Lee, S. Drug delivery: Brushing off antigenicity. Nat Biomed Eng 1, 0019 (2017). https://doi.org/10.1038/s41551-016-0019

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