Skip to main content
SpringerLink
Log in

Interleukin-18 produced by gastric epithelial cells protects against pre-neoplastic lesions in Helicobacter pylori infection in mice

  • Author’s View
  • Published:
Genes & Immunity Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: NOD1 interacts with caspase-1 to mediate H. pylori induction of IL-18 processing in gastric epithelial cells.

References

  1. Tran LS, Ying L, D’Costa K, Wray-McCann G, Kerr G, Le L, et al. NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice. Nat Commun. 2023;14:3804.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Li X, Liu S, Luo J, Liu A, Tang S, Liu S, et al. Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway. Pathog Dis. 2015;73:ftu024.

    Article  PubMed  Google Scholar 

  3. Tomita T, Jackson AM, Hida N, Hayat M, Dixon MF, Shimoyama T, et al. Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection. J Infect Dis. 2001;183:620–7.

    Article  CAS  PubMed  Google Scholar 

  4. Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, et al. Epithelial IL-18 equilibrium controls barrier function in colitis. Cell. 2015;163:1444–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity. 2010;32:367–78.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Innate Immunity, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, VIC, 3168, Australia

    Xiaohu Zhao, Dongmei Tong & Richard L. Ferrero

  2. Department of Molecular and Translational Science, Monash University, Clayton, VIC, 3800, Australia

    Xiaohu Zhao, Dongmei Tong & Richard L. Ferrero

  3. Department of Microbiology, Biomedicine Discovery Institute (3168), Monash University, Clayton, VIC, Australia

    Richard L. Ferrero

Authors
  1. Xiaohu Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dongmei Tong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard L. Ferrero
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

XZ prepared manuscript drafts, with editing performed by DT and RLF.

Corresponding author

Correspondence to Richard L. Ferrero.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhao, X., Tong, D. & Ferrero, R.L. Interleukin-18 produced by gastric epithelial cells protects against pre-neoplastic lesions in Helicobacter pylori infection in mice. Genes Immun (2024). https://doi.org/10.1038/s41435-024-00253-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41435-024-00253-y

  • Springer Nature Limited

Search

Navigation