Abstract
We aimed to evaluate the association between serum lipophilic antioxidants and liver function and prevalent non-alcoholic fatty liver disease (NAFLD). The Nutrition and Health Examination Surveys data were used (randomly selected population, 2001 and 2006). A total of 9658 participants were included, of whom 44.6% had prevalent NAFLD. In adjusted logistic regression models, participants in the top quarter of vitamin A and E had 56% (95% confidence interval (95%CI): 45–68) and 34% (95%CI: 29–57) lower odds of NAFLD compared with participants in the bottom quarter. When levels of vitamin A changed from low (1.53) to high (1.95), the fatty liver index (FLI) in the low body mass index (BMI) category changed from 36.1 to 24.3. However, at the high BMI level, FLI changed from 84.3 to 65.1 suggesting that obesity modulates the effects of vitamin A on FLI. This study suggests a protective effect of antioxidants against NAFLD occurrence, which is likely modulated by adiposity. Given the cross-sectional design, our results need to be validated in prospective studies.
Access this article
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
References
Toplak H, Stauber R, Sourij H. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease: guidelines, clinical reality and health economic aspects. Diabetologia. 2016;59:1148–9.
Li J, Cordero P, Nguyen V, Oben JA. The role of vitamins in the pathogenesis of non-alcoholic fatty liver disease. Integr Med Insights. 2016;11:19–25.
Mazidi M, Michos ED, Banach M. The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Arch Med Sci. 2017;13:61–5.
Ruhl C, Everhart J. Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey. Aliment Pharmacol Ther. 2015;41:65–76.
Videla LA, Rodrigo R, Orellana M, Fernandez V, Tapia G, Quinones L, et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin Sci (Lond). 2004;106:261–8.
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. New Engl J Med. 2010;362:1675–85.
Foster T, Budoff MJ, Saab S, Ahmadi N, Gordon C, Guerci AD. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am J Gastroenterol. 2011;106:71–7.
Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. J Am Med Assoc. 2011;305:1659–68.
Sato K, Gosho M, Yamamoto T, Kobayashi Y, Ishii N, Ohashi T, et al. Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials. Nutrition. 2015;31:923–30.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Mazidi, M., Huybrechts, I. & Kengne, A.P. Associations between serum lipophilic antioxidants levels and non-alcoholic fatty liver disease are moderated by adiposity. Eur J Clin Nutr 73, 1088–1090 (2019). https://doi.org/10.1038/s41430-019-0413-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41430-019-0413-1
- Springer Nature Limited