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New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403

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Abstract

Three new carboxylic acid derivatives, pestallic acids F and G (1 and 2), pestalotiopyrone N (3), and a new diphenylketone derivative named neopestalone (5) were obtained from the liquid cultures of marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403, along with six known compounds (4, 6–10). The structures of those new compounds were elucidated mainly by analysis of their NMR and MS data. The isolated compounds were evaluated for their anti-Dengue virus and COX-2 inhibitory activities, and two diphenylketone derivatives (5 and 6) exhibited obvious COX-2 inhibitory activities, with the IC50 values being 5.8 and 3.4 μM, respectively.

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Acknowledgements

This work was supported by grants from the Drug Innovation Major Project of China (2018ZX09735001-002003), National Natural Science Foundation of China (81973235, 21772210, 21977102), and Guangdong Basic and Applied Basic Research Foundation (2019B151502042 and 2018A0303130219) and National Key Research and Development Program of China (2019YFC0312503). We are grateful to the analytical facilities (Z. Xiao, A. Sun, Y. Zhang) in SCSIO.

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Authors and Affiliations

  1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China

    Jianjiao Wang, Qingyun Peng, Yonghong Liu & Xuefeng Zhou

  2. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China

    Jianjiao Wang, Qingyun Peng, Yonghong Liu & Xuefeng Zhou

  3. University of Chinese Academy of Sciences, 100049, Beijing, China

    Jianjiao Wang, Qingyun Peng & Yonghong Liu

  4. State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China

    Xingang Yao

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  1. Jianjiao Wang
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  2. Qingyun Peng
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  4. Yonghong Liu
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Correspondence to Xuefeng Zhou.

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Dedicated to Professor William Fenical in recognition of his contributions to marine natural products discovery and drug development.

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Wang, J., Peng, Q., Yao, X. et al. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. J Antibiot 73, 585–588 (2020). https://doi.org/10.1038/s41429-020-0308-3

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