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Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer

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Fig. 1: Characterizing CD4+ T-cell stemness in adoptive T-cell immunotherapy against melanoma.

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Acknowledgements

This study received support from an internal fund provided by the Houston Methodist Research Institute (to W.C.). The authors would like to thank the Houston Methodist Flow Cytometry Core Facility for providing excellent services.

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Authors and Affiliations

  1. Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA

    Dawei Zou, Xiaolong Zhang, Xiang Xiao, Nancy M. Gonzalez, Laurie J. Minze, Xian C. Li & Wenhao Chen

  2. Department of Cardiovascular Science, Houston Methodist Research Institute, Houston, TX, USA

    Shuang Li

  3. Department of Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA

    Xian C. Li & Wenhao Chen

Authors
  1. Dawei Zou
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  2. Xiaolong Zhang
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  3. Shuang Li
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  4. Xiang Xiao
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  5. Nancy M. Gonzalez
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  6. Laurie J. Minze
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  7. Xian C. Li
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  8. Wenhao Chen
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Contributions

DZ, XX, XCL and WC designed the study and wrote the manuscript. DZ performed the core experiments and data analysis. XZ, SL, NMG, and LJM supported the experimental work and data analysis. All the authors have read and approved the final manuscript.

Corresponding author

Correspondence to Wenhao Chen.

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Competing interests

The authors declare no competing interests. XCL is an editorial board member of Cellular & Molecular Immunology, but he has not been involved in the peer review or the decision-making of the article.

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Zou, D., Zhang, X., Li, S. et al. Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer. Cell Mol Immunol 21, 527–529 (2024). https://doi.org/10.1038/s41423-024-01154-w

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  • DOI: https://doi.org/10.1038/s41423-024-01154-w

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