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Insm1: orchestrating cellular mimicry in the thymus medulla

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References

  1. James KD, Cosway EJ, Parnell SM, White AJ, Jenkinson WE, Anderson G. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity. Bioessays. 2024;46:e2300165.

    Article  PubMed  Google Scholar 

  2. Givony T, Leshkowitz D, Del Castillo D, Nevo S, Kadouri N, Dassa B, et al. Thymic mimetic cells function beyond self-tolerance. Nature. 2023;622:164–72.

    Article  CAS  PubMed  Google Scholar 

  3. Michelson DA, Hase K, Kaisho T, Benoist C, Mathis D. Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells. Cell. 2022;185:2542–58.e18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tao W, Ye Z, Wei Y, Wang J, Yang W, Yu G, et al. Insm1 regulates mTEC development and immune tolerance. Cell Mol Immunol. 2023;20:1472–86.

    Article  CAS  PubMed  Google Scholar 

  5. Michelson DA, Zuo C, Verzi M, Benoist C, Mathis D. Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus. J Exp Med. 2023;220:e20230461.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002;298:1395–401.

    Article  CAS  PubMed  Google Scholar 

  7. Ragazzini R, Boeing S, Zanieri L, Green M, D’Agostino G, Bartolovic K, et al. Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus. Dev Cell. 2023;58:2428–46.e9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kashima J, Hashimoto T, Yoshida A, Goto Y, Ushiku T, Ohe Y, et al. Insulinoma-associated-1 (INSM1) expression in thymic squamous cell carcinoma. Virchows Arch. 2022;481:893–901.

    Article  CAS  PubMed  Google Scholar 

  9. Cowan JE, Jenkinson WE, Anderson G. Thymus medulla fosters generation of natural Treg cells, invariant gammadelta T cells, and invariant NKT cells: what we learn from intrathymic migration. Eur J Immunol. 2015;45:652–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Farr AG, Rudensky A. Medullary thymic epithelium: a mosaic of epithelial “self”? J Exp Med. 1998;188:1–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank Professor Avinash Bhandoola and Professor Graham Anderson for their critical comments. JEC is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 222623/Z/21/Z). KDJ is a Post-Doctoral Fellow supported by an MRC Programme Grant (MR/T029765/1) awarded to Professor Graham Anderson.

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  1. UCL Institute of Immunity and Transplantation, The Pears Building, Rowland Hill Street, London, NW3 2PP, UK

    K. D. James & J. E. Cowan

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  1. K. D. James
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  2. J. E. Cowan
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Correspondence to J. E. Cowan.

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James, K.D., Cowan, J.E. Insm1: orchestrating cellular mimicry in the thymus medulla. Cell Mol Immunol 21, 416–418 (2024). https://doi.org/10.1038/s41423-024-01151-z

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