References
Pawankar RCG, Holgate ST, Lockey RF, Blaiss M. The WAO White Book on Allergy. 2013:1-248.
Collaborators GBDCoD. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1736–88.
Liew FY, Girard JP, Turnquist HR. Interleukin-33 in health and disease. Nat Rev Immunol. 2016;16:676–89.
Dwyer GK, D’Cruz LM, Turnquist HR. Emerging Functions of IL-33 in Homeostasis and Immunity. Annu Rev Immunol. 2022;40:15–43.
Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, Bleecker ER, et al. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol. 2008;122:651–4.e8
Belpinati F, Malerba G, Trabetti E, Galavotti R, Xumerle L, Pescollderungg L, et al. Association of childhood allergic asthma with markers flanking the IL33 gene in Italian families. J Allergy Clin Immunol. 2011;128:667–8.
Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, et al. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012;90:273–81.
Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, et al. IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci USA. 2010;107:18581–6.
Wechsler ME, Ruddy MK, Pavord ID, Israel E, Rabe KF, Ford LB, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N. Engl J Med. 2021;385:1656–68.
Bessa J, Meyer CA, de Vera Mudry MC, Schlicht S, Smith SH, Iglesias A, et al. Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation. J Autoimmun. 2014;55:33–41.
Zhu S, Zhong S, Cheng K, Zhang LS, Bai JW, Cao Z, et al. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. Cell Mol Immunol. 2023;20:794–807.
Reynolds RD, Natta CL. Depressed plasma pyridoxal phosphate concentrations in adult asthmatics. Am J Clin Nutr. 1985;41:684–8.
Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, et al. The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol. 2021;22:460–70.
Wang A, Yang M, Liang R, Zhu F, Zhu F, Liu X, et al. Mouse double minute 2 homolog-mediated ubiquitination facilitates forkhead box P3 stability and positively modulates human regulatory T cell function. Front Immunol. 2020;11:1087.
Choi YM, An S, Bae S, Jung JH. Mdm2 is required for HDAC3 monoubiquitination and stability. Biochem Biophys Res Commun. 2019;517:353–8.
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Work in the author’s laboratory is supported by funding from the National Institutes of Health (R01HL22489 and R01AR073527) and the Department of Defense (W81XWH-21–1–0896).
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Turnquist, H.R. Vitamin B-reath easier: vitamin B6 derivatives reduce IL-33 to limit lung inflammation. Cell Mol Immunol 20, 1527–1529 (2023). https://doi.org/10.1038/s41423-023-01076-z
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DOI: https://doi.org/10.1038/s41423-023-01076-z
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