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Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis

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References

  1. Mayassi T, Barreiro LB, Rossjohn J, Jabri B. A multilayered immune system through the lens of unconventional T cells. Nature. 2021;595:501–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Slauenwhite D, Johnston B. Regulation of NKT cell localization in homeostasis and infection. Front Immunol. 2015;6:255.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Constantinides MG, Belkaid Y. Early-life imprinting of unconventional T cells and tissue homeostasis. Sience. 2021;374:eabf0095.

    Article  CAS  Google Scholar 

  4. Wang WB, Lin YD, Zhao L, Liao C, Zhang Y, Davila M, et al. Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis. Nat Immunol. 2023;24:225–38.

    Article  CAS  PubMed  Google Scholar 

  5. Pellicci DG, Koay HF, Berzins SP. Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge. Nat Rev Immunol. 2020;20:756–70.

    Article  CAS  PubMed  Google Scholar 

  6. Yang J, Restori KH, Xu M, Song EH, Zhao L, Hu S, et al. Preferential perinatal development of skin-homing NK1.1+ innate lymphoid cells for regulation of cutaneous microbiota colonization. iScience. 2020;23:101014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell. 2010;142:24–38.

    Article  CAS  PubMed  Google Scholar 

  8. Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, et al. Dysregulated expression of the nuclear exosome targeting complex component Rbm7 in nonhematopoietic cells licenses the development of fibrosis. Immunity. 2020;52:542–56.e13.

    Article  CAS  PubMed  Google Scholar 

  9. Niitsu T, Fukushima K, Komukai S, Takata S, Abe Y, Nii T, et al. Real-world impact of antifibrotics on prognosis in patients with progressive fibrosing interstitial lung disease. RMD Open. 2023;9:e002667.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ali MK, Kim RY, Brown AC, Donovan C, Vanka KS, Mayall JR, et al. Critical role for iron accumulation in the pathogenesis of fibrotic lung disease. J Pathol. 2020;251:49–62.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Funding

This work was supported in part by AMED (grant numbers JP20fk0108129, JP21fk0108129h0702, and JP21lm0203007), a GSK Research grant (grant number A-32), the Japan Intractable Diseases (Nanbyo) Research Foundation (grant number 2020B02), JSPS KAKENHI (grant numbers JP21K16118 and JP21K08194), the Smoking Research Foundation (2021Y007), the Takeda Science Foundation, the Uehara Memorial Foundation, the MSD Life Science Foundation, the Japanese Respiratory Society Boehringer Ingelheim Research Grant Program, the Foundation of Kinoshita Memorial Enterprise, the Senri Life Science Foundation, and the Inamori Foundation.

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Correspondence to Hiroshi Kida.

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Nabeshima, H., Niitsu, T., Fukushima, K. et al. Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis. Cell Mol Immunol 20, 1095–1097 (2023). https://doi.org/10.1038/s41423-023-01016-x

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  • DOI: https://doi.org/10.1038/s41423-023-01016-x

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