Skip to main content
SpringerLink
Log in

MiR-30a-centered molecular crosstalk regulates Th17 differentiation

  • Comment
  • Published:
Cellular & Molecular Immunology Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Fu J, Huang Y, Bao T, Liu C, Liu X, Chen XJ. The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A. J Neuroinflammation. 2022;19:98.

    Article  CAS  Google Scholar 

  2. Wei B, Pei G. microRNAs: critical regulators in Th17 cells and players in diseases. Cell Mol Immunol. 2010;7:175–81.

    Article  CAS  Google Scholar 

  3. Basak J, Majsterek I. miRNA-dependent CD4(+) T cell differentiation in the pathogenesis of multiple sclerosis. Mult Scler Int. 2021;2021:8825588.

    PubMed  PubMed Central  Google Scholar 

  4. Han J, Zhuang W, Feng W, Dong F, Hua F, Yao R, et al. The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis. Cell Mol Immunol. 2021;18:2177–87.

    Article  CAS  Google Scholar 

  5. Shen N, Liang D, Tang Y, de Vries N, Tak PPN. MicroRNAs–novel regulators of systemic lupus erythematosus pathogenesis. Nat Rev Rheumatol. 2012;8:701–9.

    Article  CAS  Google Scholar 

  6. Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009;10:1252–9.

    Article  CAS  Google Scholar 

  7. Qu X, Zhou J, Wang T, Han J, Ma L, Yu H, et al. MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R. Brain Behav Immun. 2016;57:193–9.

    Article  CAS  Google Scholar 

  8. Quintana E, Ortega FJ, Robles-Cedeno R, Villar ML, Buxo M, Mercader JM, et al. miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands. Mult Scler. 2017;23:1716–26.

    Article  CAS  Google Scholar 

  9. Zheng Y, Wang Z, Zhou ZY. miRNAs: novel regulators of autoimmunity-mediated pancreatic beta-cell destruction in type 1 diabetes. Cell Mol Immunol. 2017;14:488–96.

    Article  CAS  Google Scholar 

  10. Liu X, Su X, Xu S, Wang H, Han D, Li J, et al. MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target Stat3 and inhibits innate IL-6 production. Cell Mol Immunol. 2018;15:99–110.

    Article  CAS  Google Scholar 

  11. Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 2020;21:475–90.

    Article  CAS  Google Scholar 

  12. Qu X, Han J, Zhang Y, Wang X, Fan H, Hua F, et al. TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development. J Neuroinflammation. 2019;16:183.

    Article  Google Scholar 

Download references

Acknowledgements

We thank Figdraw (www.figdraw.com) for providing scientific drawing materials. This work was supported by the National Natural Science Foundation of China (81302519), Natural Science Foundation of Jiangsu Province (BK20130221), 333 Project of Jiangsu Province, Scientific Research Funds of Xuzhou Medical University and Jiangsu Vocational College of Medicine.

Author information

Authors and Affiliations

  1. Department of Basic Medical Science, Jiangsu Vocational College of Medicine, Yancheng, 224008, Jiangsu, China

    Jingjing Han, Liucai Yang & Xuebin Qu

  2. Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China

    Jingjing Han

  3. Department of Cell Biology and Neurobiology, Xuzhou Medical University, Xuzhou, 221009, Jiangsu, China

    Wanhua Feng, Ruiqin Yao & Xuebin Qu

Authors
  1. Jingjing Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wanhua Feng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ruiqin Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liucai Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xuebin Qu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Liucai Yang or Xuebin Qu.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Han, J., Feng, W., Yao, R. et al. MiR-30a-centered molecular crosstalk regulates Th17 differentiation. Cell Mol Immunol 19, 960–961 (2022). https://doi.org/10.1038/s41423-022-00888-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41423-022-00888-9

  • Springer Nature Limited

Search

Navigation