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Cuproptosis: a new form of programmed cell death

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Fig. 1: Schematic model of copper-induced cell death.

References

  1. Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375:1254–61. https://doi.org/10.1126/science.abf0529

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Bock FJ, Tait SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020;21:85–100. https://doi.org/10.1038/s41580-019-0173-8

    Article  CAS  PubMed  Google Scholar 

  3. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72. https://doi.org/10.1016/j.cell.2012.03.042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019;15:681–9. https://doi.org/10.1038/s41589-019-0291-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nagai M, Vo NH, Shin Ogawa L, Chimmanamada D, Inoue T, et al. The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells. Free Radic Biol Med. 2012;52:2142–50. https://doi.org/10.1016/j.freeradbiomed.2012.03.017

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by a special program from the Ministry of Science and Technology of China (2021YFA101000), the Chinese National Natural Science Funds (U20A20393, U20A201376, 31925013, 3212500161, 82041009, 31871405, 31701234, 81902947, 82041009, 31671457, 31571460 and 91753139), the Jiangsu Provincial Distinguished Young Scholars Award (BK20180043), the Key Project of the University Natural Science Foundation of Jiangsu Province (19KJA550003), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX17_2036).

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Authors and Affiliations

  1. Institutes of Biology and Medical Science, Soochow University, Suzhou, 215123, China

    Yongqiang Wang & Fangfang Zhou

  2. MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China

    Long Zhang

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  1. Yongqiang Wang
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  2. Long Zhang
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Correspondence to Long Zhang or Fangfang Zhou.

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Wang, Y., Zhang, L. & Zhou, F. Cuproptosis: a new form of programmed cell death. Cell Mol Immunol 19, 867–868 (2022). https://doi.org/10.1038/s41423-022-00866-1

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