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Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

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References

  1. Crinier, A. et al. Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia. Cell. Mol. Immunol. 18, 1290–1304 (2021).

    Google Scholar 

  2. Crinier, A. et al. High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice. Immunity 49, 971–986.e5 (2018).

    Article  CAS  Google Scholar 

  3. Melsen, J. E. et al. Human Bone Marrow-Resident Natural Killer Cells Have a Unique Transcriptional Profile and Resemble Resident Memory CD8+ T Cells. Front. Immunol. 9, 1829 (2018).

    Article  Google Scholar 

  4. Lugthart, G. et al. Human Lymphoid Tissues Harbor a Distinct CD69 + CXCR6 + NK Cell Population. J. Immunol. 197, 78–84 (2016).

    Article  CAS  Google Scholar 

  5. Wein, A. N. et al. CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways. J. Exp. Med. 216, 2748–2762 (2019).

    Article  CAS  Google Scholar 

  6. Shiow, L. R. et al. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440, 540–544 (2006).

    Article  CAS  Google Scholar 

  7. Dogra, P. et al. Tissue Determinants of Human NK Cell Development, Function, and Residence. Cell 180, 749–763.e13 (2020).

    Article  CAS  Google Scholar 

  8. Haghverdi, L., Lun, A. T. L., Morgan, M. D. & Marioni, J. C. Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors. Nat. Biotechnol. 36, 421–427 (2018).

    Article  CAS  Google Scholar 

  9. Hotta, R. et al. CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment. PLoS ONE 11, e0161618 (2016).

    Article  Google Scholar 

  10. Hanna, J. et al. Novel insights on human NK cells’ immunological modalities revealed by gene expression profiling. J. Immunol. 173, 6547–6563 (2004).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory for Pediatric Immunology, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands

    Janine E. Melsen, Gertjan Lugthart, Monique M. van Ostaijen-ten Dam & Marco W. Schilham

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  1. Janine E. Melsen
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  2. Gertjan Lugthart
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  3. Monique M. van Ostaijen-ten Dam
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  4. Marco W. Schilham
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Correspondence to Janine E. Melsen.

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Melsen, J.E., Lugthart, G., van Ostaijen-ten Dam, M.M. et al. Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia. Cell Mol Immunol 18, 1348–1349 (2021). https://doi.org/10.1038/s41423-021-00653-4

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