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Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history

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References

  1. Klareskog, L. et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 54, 38–46 (2006).

    Article  CAS  Google Scholar 

  2. Vassallo, R. et al. Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes. Clin. Immunol. 152, 25–35 (2014).

    Article  CAS  Google Scholar 

  3. Fu, J. et al. Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis. Proc. Natl Acad. Sci. USA 115, 4755–4760 (2018).

    Article  CAS  Google Scholar 

  4. Volchenkov, R., Nygaard, V., Sener, Z. & Skalhegg, B. S. Th17 polarization under hypoxia results in increased il-10 production in a pathogen-independent manner. Front Immunol. 8, 698 (2017).

    Article  Google Scholar 

  5. Weng, C. H., Gupta, S., Geraghty, P., Foronjy, R. & Pernis, A. B. Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production. Mol. Immunol. 71, 115–122 (2016).

    Article  CAS  Google Scholar 

  6. Kroon, L. A. Drug interactions with smoking. Am. J. Health Syst. Pharm. 64, 1917–1921 (2007).

    Article  CAS  Google Scholar 

  7. Team R.D.C. R: A Language and Environment for Statistical Computing. (The R Foundation for Statistical Computing, Vienna, 2011).

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Acknowledgements

We thank Leonid Padyukov and Lars Klareskog (Karolinska University) for their advice and Jorunn Johansen (Department of Immunology, Oslo University Hospital) for help with HLA typing. This study was supported by the University of Oslo (IMB-2016 to BS), the Norwegian Research Council (ES 572317), and the Throne Holst Foundation (THS-2016/17 to BS).

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Correspondence to Bjørn S. Skålhegg.

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Volchenkov, R., Matthews, J., Zucknick, M. et al. Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history. Cell Mol Immunol 16, 674–675 (2019). https://doi.org/10.1038/s41423-019-0230-4

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  • DOI: https://doi.org/10.1038/s41423-019-0230-4

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