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Cellular and Molecular Biology

Tumour budding in head and neck cancer: what have we learnt and the next steps towards clinical implementation

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Fig. 1: Tumour budding in head and neck squamous cell carcinomas.

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References

  1. Stogbauer F, Beck S, Ourailidis I, Hess J, Poremba C, Lauterbach M, et al. Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer. Br J Cancer. 2023;128:2295–306.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Almangush A, Pirinen M, Heikkinen I, Makitie AA, Salo T, Leivo I. Tumour budding in oral squamous cell carcinoma: a meta-analysis. Br J Cancer. 2018;118:577–86.

    Article  PubMed  Google Scholar 

  3. Jesinghaus M, Steiger K, Stogbauer F, Haller B, Kolk A, Strassen U, et al. Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma. Br J Cancer. 2020;122:835–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lugli A, Zlobec I, Berger MD, Kirsch R, Nagtegaal ID. Tumour budding in solid cancers. Nat Rev Clin Oncol. 2021;18:101–15.

    Article  PubMed  Google Scholar 

  5. Rogers AC, Winter DC, Heeney A, Gibbons D, Lugli A, Puppa G, et al. Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer. Br J Cancer. 2016;115:831–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Almangush A, Karhunen M, Hautaniemi S, Salo T, Leivo I. Prognostic value of tumour budding in oesophageal cancer: a meta-analysis. Histopathology. 2016;68:173–82.

    Article  PubMed  Google Scholar 

  7. Zhu Y, Liu H, Xie N, Liu X, Huang H, Wang C, et al. Impact of tumor budding in head and neck squamous cell carcinoma: a meta-analysis. Head Neck. 2019;41:542–50.

    Article  PubMed  Google Scholar 

  8. Lugli A, Kirsch R, Ajioka Y, Bosman F, Cathomas G, Dawson H, et al. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod Pathol. 2017;30:1299–311.

    Article  PubMed  Google Scholar 

  9. Seki M, Sano T, Yokoo S, Oyama T. Histologic assessment of tumor budding in preoperative biopsies to predict nodal metastasis in squamous cell carcinoma of the tongue and floor of the mouth. Head Neck. 2016;38:E1582–90.

    Article  PubMed  Google Scholar 

  10. Zlobec I, Hadrich M, Dawson H, Koelzer VH, Borner M, Mallaev M, et al. Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients. Br J Cancer. 2014;110:1008–13.

    Article  CAS  PubMed  Google Scholar 

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The three authors have contributed to the writing of the manuscript and have approved the final version for submission to the British Journal of Cancer.

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Correspondence to Alhadi Almangush.

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Almangush, A., Mäkitie, A.A. & Leivo, I. Tumour budding in head and neck cancer: what have we learnt and the next steps towards clinical implementation. Br J Cancer 130, 1–2 (2024). https://doi.org/10.1038/s41416-023-02531-4

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  • DOI: https://doi.org/10.1038/s41416-023-02531-4

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