Skip to main content

Advertisement

SpringerLink
Log in

Pan-cancer analysis of TRPV2 identifies its potential role as a prognostic and immunologic biomarker in oesophageal cancer

  • Correspondence
  • Published:
British Journal of Cancer Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: The role of TRPV2 in pan-cancer analysis.

Data availability

Data used in this study are publicly available from the TCGA database (https://portal.gdc.cancer.gov/).

References

  1. Islami F, Poustchi H, Pourshams A, Khoshnia M, Gharavi A, Kamangar F, et al. A prospective study of tea drinking temperature and risk of esophageal squamous cell carcinoma. Int J Cancer. 2020;146:18–25.

    Article  CAS  PubMed  Google Scholar 

  2. Yu C, Tang H, Guo Y, Bian Z, Yang L, Chen Y, et al. Hot Tea consumption and its interactions with alcohol and tobacco use on the risk for esophageal cancer: a population-based cohort study. Ann Intern Med. 2018;168:489–97.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, et al. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Br J Cancer. 2022;127:1424–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12:453–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kojima I, Nagasawa M. TRPV2. Handb Exp Pharm. 2014;222:247–72.

    Article  CAS  Google Scholar 

  6. Siveen KS, Nizamuddin PB, Uddin S, Al-Thani M, Frenneaux MP, Janahi IA, et al. TRPV2: a cancer biomarker and potential therapeutic target. Dis Markers. 2020;2020:8892312.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Santoni G, Farfariello V, Liberati S, Morelli MB, Nabissi M, Santoni M, et al. The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Front Immunol. 2013;4:34.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol. 2010;11:232–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cahalan MD, Chandy KG. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009;231:59–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We would like to thank Sangerbox (http://vip.sangerbox.com/) for the support of data visualisation.

Funding

This work was supported by CAMS Innovation Fund for Medical Sciences (CIFMS) (No. 2021-I2M-C&T-B-018).

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China

    Hang Yi & Yousheng Mao

  2. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China

    Yiwen Lin

  3. Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, China

    Xuefei Wang

Authors
  1. Hang Yi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yiwen Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuefei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yousheng Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

HY and YL were involved in conceptualising, literature review and drafting the letter, and YM revised the letter for final submission. All authors approved the final version for submission and publication of the content.

Corresponding author

Correspondence to Yousheng Mao.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yi, H., Lin, Y., Wang, X. et al. Pan-cancer analysis of TRPV2 identifies its potential role as a prognostic and immunologic biomarker in oesophageal cancer. Br J Cancer 129, 567–569 (2023). https://doi.org/10.1038/s41416-023-02302-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41416-023-02302-1

  • Springer Nature Limited

Search

Navigation