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Von Willebrand factor as a potential predictive biomarker of early complications of endothelial origin after allogeneic hematopoietic stem cell transplantation

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Fig. 1: VWF is a risk factor of post-alloSCT endothelial syndrome and poor OS.

References

  1. Pagliuca S, Michonneau D, Sicre de Fontbrune F, Sutra Del Galy A, Xhaard A, Robin M, et al. Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. Blood Adv. 2019;3:2424–35. https://doi.org/10.1182/bloodadvances.2019000143.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fraebel J, Engelhardt BG, Kim TK. Noninfectious pulmonary complications after hematopoietic stem cell transplantation. Transpl Cell Ther. 2023;29:82–93. https://doi.org/10.1016/j.jtct.2022.11.012.

    Article  Google Scholar 

  3. Elsawy M, Sorror ML. Up-to-date tools for risk assessment before allogeneic hematopoietic cell transplantation. Bone Marrow Transpl. 2016;51:1283–1300. https://doi.org/10.1038/bmt.2016.141.

    Article  CAS  Google Scholar 

  4. Sorror ML, Sandmaier BM, Storer BE, Maris MB, Baron F, Maloney DG, et al. Comorbidity and disease status based risk stratification of outcomes among patients with acute myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic cell transplantation. J Clin Oncol. 2007;25:4246–54. https://doi.org/10.1200/JCO.2006.09.7865.

    Article  PubMed  Google Scholar 

  5. Luft T, Benner A, Terzer T, Jodele S, Dandoy CE, Storb R, et al. EASIX and mortality after allogeneic stem cell transplantation. Bone Marrow Transpl. 2020;55:553–61. https://doi.org/10.1038/s41409-019-0703-1.

    Article  CAS  Google Scholar 

  6. Chen J, Chung DW. Inflammation, von Willebrand factor, and ADAMTS13. Blood. 2018;132:141–7. https://doi.org/10.1182/blood-2018-02-769000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Luft T, Dreger P, Radujkovic A. Endothelial cell dysfunction: a key determinant for the outcome of allogeneic stem cell transplantation. Bone Marrow Transpl. 2021;56:2326–35. https://doi.org/10.1038/s41409-021-01390-y.

    Article  Google Scholar 

  8. Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, et al. Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. Transpl Cell Ther. 2023;29:151–63. https://doi.org/10.1016/j.jtct.2022.11.015.

    Article  CAS  Google Scholar 

  9. Aird WC. Endothelial cell heterogeneity. Cold Spring Harb Perspect Med. 2012;2:a006429. https://doi.org/10.1101/cshperspect.a006429.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, et al. Functional genomic landscape of acute myeloid leukaemia. Nature. 2018;562:526–31. https://doi.org/10.1038/s41586-018-0623-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jodele S, Zhang K, Zou F, Laskin B, Dandoy CE, Myers KC, et al. The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy. Blood. 2016;127:989–96. https://doi.org/10.1182/blood-2015-08-663435.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Pennisi M, Sanchez-Escamilla M, Flynn JR, Shouval R, Alarcon Tomas A, Silverberg ML, et al. Modified EASIX predicts severe cytokine release syndrome and neurotoxicity after chimeric antigen receptor T cells. Blood Adv. 2021;5:3397–406. https://doi.org/10.1182/bloodadvances.2020003885.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Service d’Hématologie, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    Guillaume Dachy, Marine Vankeerbergen, Nicolas Vanlangendonck, Nicole Straetmans, Catherine Lambert, Cédric Hermans & Xavier Poiré

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  1. Guillaume Dachy
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  2. Marine Vankeerbergen
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  3. Nicolas Vanlangendonck
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  4. Nicole Straetmans
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Contributions

GD took care of the patients, collected and analyzed the data and wrote the manuscript ; MV took care of the patients and collected the data ; NV collected the data ; NS took care of the patients and helped write the manuscript ; CL took care of the patients and helped write the manuscript ; CH took care of the patients and helped write the manuscript ; XP took care of the patients, designed the study and wrote the manuscript.

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Correspondence to Guillaume Dachy.

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Dachy, G., Vankeerbergen, M., Vanlangendonck, N. et al. Von Willebrand factor as a potential predictive biomarker of early complications of endothelial origin after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 59, 890–892 (2024). https://doi.org/10.1038/s41409-024-02242-1

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