Skip to main content
SpringerLink
Log in

Maximum-tolerated dose of lomustine used in combination with etoposide and cyclophosphamide in conditioning regimen for hematopoietic stem cell transplantation in lymphoma patients

  • Correspondence
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ansell SM. Hodgkin Lymphoma: A 2020 update on diagnosis, risk-stratification, and management. Am J Hematol. 2020;95:978–989.

    Article  Google Scholar 

  2. Chen YB, Lane AA, Logan B, Zhu X, Akpek G, Aljurf M, Artz A, et al. Impact of conditioning regimen on outcomes for patients with lymphoma undergoing high-dose therapy with autologous hematopoietic cell transplantation. Biol Blood Marrow Transpl. 2015;21:1046–1053.

    Article  Google Scholar 

  3. Perz JB, Giles C, Szydlo R, O'Shea D, Sanz J, Chaidos A, et al. LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin’s lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre. Bone Marrow Transplant. 2007;39:41–47.

    Article  CAS  Google Scholar 

  4. Stuart MJ, Chao NS, Horning SJ, Wong RM, Negrin RS, Johnston LJ, et al. Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin’s disease. Biol Blood Marrow Transplant. 2001;7:552–560.

    Article  CAS  Google Scholar 

  5. Santos KB, Pereira J, Atalla A, Costa LJ, Hallack-Neto AE. The use of lomustine in combination with etoposide, cytarabine and melphalan in a brief conditioning for auto-HSCT in patients with lymphoma: the optimal dose. Bone Marrow Transpl. 2014;49:1239–40.

    Article  Google Scholar 

  6. Dos Santos KB, Costa LJM, Bettarello G, da Matta Abreu M, Mayrink GTC, Mota MA, Ribeiro LC, et al. LEAM versus CBV for conditioning in autologous hematopoietic stem cell transplantation for lymphoma. Bone Marrow Transplant. 2019;54:625–628.

    Article  Google Scholar 

  7. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. 2017. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm National Cancer Institute. Division of cancer treatment and diagnosis.

Download references

Author information

Authors and Affiliations

  1. Federal University of Juiz de Fora, Juiz de Fora, Brazil

    Christianne Tolêdo de Souza Leal, Raphael Barros Tavares & Abrahão Elias Hallack Neto

  2. University of Alabama at Birmingham, EUA, Birmingham, AL, USA

    Luciano José Megale Costa

  3. São Paulo University, São Paulo, Brazil

    Juliana Pereira

  4. Federal University of Ceará, Fortaleza, Brazil

    Fernando Barroso Duarte

  5. Monte Sinai Hospital, Juiz de Fora, Brazil

    Angelo Atalla

  6. São José Hospital, Teresópolis, Brazil

    Bruna Sousa Sabioni

Authors
  1. Christianne Tolêdo de Souza Leal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luciano José Megale Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Juliana Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fernando Barroso Duarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Raphael Barros Tavares
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Angelo Atalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bruna Sousa Sabioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Abrahão Elias Hallack Neto
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

CTdeSL—Main author, participated in the research elaboration, application of the consent form to patients, data collection and text writing. LJMC—Participated in the research elaboration, text writting and translation to English. JP—Participated in the research elaboration, ideas to the structure of the article. FBD—participated in the research elaboration, ideas to the structure of the article. RBT—Participated in the research elaboration, application of the consent form to patients, data collection and text writing. AA—Head of hematology at Monte Sinai Hospital- o research center that offered patient. BSS—Participated in the research elaboration, application of the consent form to patients, data collection. AEHN—Head of hematology service at University Hospital of the Federal University of Juiz de Fora. PhD adviser. Participated in the research elaboration, application of the consent form to patients, data collection and text writing.

Corresponding author

Correspondence to Christianne Tolêdo de Souza Leal.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Leal, C.T.d.S., Costa, L.J.M., Pereira, J. et al. Maximum-tolerated dose of lomustine used in combination with etoposide and cyclophosphamide in conditioning regimen for hematopoietic stem cell transplantation in lymphoma patients. Bone Marrow Transplant 57, 309–311 (2022). https://doi.org/10.1038/s41409-021-01531-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-021-01531-3

  • Springer Nature Limited

Search

Navigation