Skip to main content
Log in

Endogenous thrombopoietin levels are elevated following double cord blood unit transplantation

  • Correspondence
  • Published:
Bone Marrow Transplantation Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Eapen M, Rocha V, Sanz G, Scaradavou A, Zhang MJ, Arcese W, et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol. 2010;11:653–60.

    Article  Google Scholar 

  2. Al-Samkari H, Kuter DJ. Optimal use of thrombopoietin receptor agonists in immune thrombocytopenia. Ther Adv Hematol. 2019; 10:2040620719841735.

    Article  CAS  Google Scholar 

  3. Calmettes C, Vigouroux S, Tabrizi R, Milpied N. Romiplostim (AMG531, Nplate) for secondary failure of platelet recovery after allo-SCT. Bone Marrow Transpl. 2011;46:1587–9.

    Article  CAS  Google Scholar 

  4. Poon LM, Di Stasi A, Popat U, Champlin RE, Ciurea SO. Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation. Am J Blood Res. 2013;3:260–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Hartranft ME, Clemmons AB, DeRemer DL, Kota V. Evaluation of romiplostim for the treatment of secondary failure of platelet recovery among allogeneic hematopoietic stem cell transplant patients. J Oncol Pharm Pr. 2017;23:10–7.

    Article  CAS  Google Scholar 

  6. Tanaka T, Inamoto Y, Yamashita T, Fuji S, Okinaka K, Kurosawa S, et al. Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transpl. 2016;22:919–24.

    Article  CAS  Google Scholar 

  7. Rivera D, Bastida JM, Lopez-Corral L, Sanchez-Guijo F, Cabrero M, Martin A, et al. Usefulness of eltrombopag for treating thrombocytopenia after allogeneic stem cell transplantation. Bone Marrow Transpl. 2019;54:757–61.

    Article  CAS  Google Scholar 

  8. Anasetti C, Logan BR, Lee SJ, Waller EK, Weisdorf DJ, Wingard JR, et al. Peripheral-blood stem cells versus bone marrow from unrelated donors. New Engl J Med. 2012;367:1487–96.

    Article  CAS  Google Scholar 

  9. Al-Samkari H, Kuter DJ. Thrombopoietin level predicts response to treatment with eltrombopag and romiplostim in immune thrombocytopenia. Am J Hematol. 2018;93:1501–8.

    Article  CAS  Google Scholar 

  10. Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 2007;1:685–97.

    Article  CAS  Google Scholar 

  11. Alvarado LJ, Huntsman HD, Cheng H, Townsley DM, Winkler T, Feng X, et al. Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-gamma. Blood. 2019;133:2043–55.

    Article  CAS  Google Scholar 

  12. Song Y, Shi MM, Zhang YY, Mo XD, Wang Y, Zhang XH, et al. Abnormalities of the bone marrow immune microenvironment in patients with prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2017;23:906–12.

    Article  Google Scholar 

Download references

Acknowledgements

Amgen Inc. provided clinical trial funding.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zachariah DeFilipp.

Ethics declarations

Conflict of interest

ZD reports research funding from Incyte, Corp. DJK reports research funding (Protalex, Bristol-Myers Squibb, Rigel, Bioverativ, Agios, Syntimmune, Principia, Alnylam) and consultancy (ONO, Pfizer, 3SBios, Eisai, GlaxoSmithKline, Genzyme, Shire, Alexion, Amgen, Shionogi, Rigel, Syntimmune, MedImmune, Novartis, Bioverativ, Argenx, Zafgen). All other authors declare no conflict of interest.

Additional information

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

DeFilipp, Z., Makar, R.S., Brown, J. et al. Endogenous thrombopoietin levels are elevated following double cord blood unit transplantation. Bone Marrow Transplant 55, 1178–1180 (2020). https://doi.org/10.1038/s41409-019-0652-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-019-0652-8

  • Springer Nature Limited

Navigation