References
Darbari, A., Sabin, K. M., Shapiro, C. N. & Schwarz, K. B. Epidemiology of primary hepatic malignancies in U.S. children. Hepatology 38, 560–566 (2003).
Hu, H. M. et al. Treatment outcomes for hepatoblastoma children with pulmonary metastasis and extrapulmonary involvement: Experience of 36 cases at a single institution. Transl. Cancer Res. 9, https://doi.org/10.21037/tcr-20-1876 (2020).
Yu, J. et al. Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma. BMC Cancer. 18, https://doi.org/10.1186/s12885-018-4744-4 (2018).
Hurley, E. H. et al. Inhibition of Heat Shock Factor 1 Signaling Decreases Hepatoblastoma Growth via Induction of Apoptosis. Am. J. Pathol. 193, 148–160 (2023).
Wang, D. et al. Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors. Mol. Ther. 30, https://doi.org/10.1016/j.ymthe.2022.01.032 (2022).
Suzuki, T. et al. Establishment of a Human Hepatoblastoma Model In Athymic Nude Mice. Acta Patholigica Jpn. 42, 255–261 (1992).
Whitlock, R. S., Yang, T., Vasudevan, S. A. & Woodfield, S. E. Animal modeling of pediatric liver cancer. Cancers 12, https://doi.org/10.3390/cancers12020273 (2020).
Michalopoulos, G. K. & Bhushan, B. Liver regeneration: biological and pathological mechanisms and implications. Nat. Rev. Gastroenterol. Hepatol. 18, https://doi.org/10.1038/s41575-020-0342-4 (2021).
Gomez-Cuadrado, L., Tracey, N., Ma, R., Qian, B. & Brunton, V. G. Mouse models of metastasis: Progress and prospects. DMM Dis. Model. Mech. 10, https://doi.org/10.1242/dmm.030403 (2017).
Sumazin, P. et al. Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology 65, 104–121 (2017).
Kanawa, M. et al. Gene expression profiling in hepatoblastoma cases of the Japanese Study Group for Pediatric Liver Tumors-2 (JPLT-2) trial. Eur. J. Mol. Cancer 2018, 1–8 (2019).
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This work was supported by a Pilot & Feasibility grant from the Pittsburgh Liver Research Center, NIH/NIDDK P30DK120531 (EHH).
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Hurley, E.H. Commentary on the challenges of modeling hepatoblastoma in-vivo. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03215-2
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DOI: https://doi.org/10.1038/s41390-024-03215-2
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