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Inflammation in sudden infant death syndrome

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References

  1. Filiano, J. J. & Kinney, H. C. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol. Neonate. 65, 194–197 (1994).

    Article  CAS  PubMed  Google Scholar 

  2. Qu, D., Preuss, V., Hagemeier, L., Radomsky, L., Beushausen, K., Keil, J., Nora, S., Vennemann, B., Falk, C.S., Klintschar, M. Ha Age-related cytokine imbalance in the thymus in sudden infant death syndrome (SIDS). Pediatr. Res. (2023). Online ahead of print.

  3. Kinney, H. C. & Thach, B. T. The sudden infant death syndrome. N. Engl. J. Med. 361, 795–805 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Duncan J. R., Byard R. W. Sudden Infant Death Syndrome: An Overview. In SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future Chapter 2. (University of Adelaide Press, Adelaide (AU), 2018).

  5. Kemp, J. S. & Thach, B. T. Sudden death in infants sleeping on polystyrene-filled cushions. N. Engl. J. Med. 324, 1858–1864 (1991).

    Article  CAS  PubMed  Google Scholar 

  6. Vege, A., Chen, Y., Opdal, S. H., Saugstad, O. D. & Rognum, T. O. Vitreous humor hypoxanthine levels in SIDS and infectious death. Acta Paediatr. 83, 634–639 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. Jones, K. L. et al. Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia. Pediatrics 111, 358–363 (2003).

    Article  PubMed  Google Scholar 

  8. Cutz, E., Perrin, D. G., Pan, J., Haas, E. A. & Krous, H. F. Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction. Pediatr. Dev. Pathol. 10, 106–116 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Goldwater, P. N. SIDS, prone sleep position and infection: An overlooked epidemiological link in current SIDS research? Key evidence for the “Infection Hypothesis”. Med Hypotheses 144, 110114 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Vege, A., Rognum, T. O., Scott, H., Aasen, A. O. & Saugstad, O. D. SIDS cases have increased levels of interleukin-6 in cerebrospinal fluid. Acta Paediatr. 84, 193–196 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Forsyth, K. D. Immune and inflammatory responses in sudden infant death syndrome. FEMS Immunol. Med Microbiol. 25, 79–83 (1999).

    Article  CAS  PubMed  Google Scholar 

  12. Blood-Siegfried, J. et al. Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. FEMS Immunol. Med. Microbiol. 42, 85–93 (2004).

    Article  CAS  PubMed  Google Scholar 

  13. Blood-Siegfried, J. et al. Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome. Pediatr. Res. 52, 481–490 (2002).

    Article  CAS  PubMed  Google Scholar 

  14. Rourke, K. S., Mayer, C. A. & MacFarlane, P. M. A critical postnatal period of heightened vulnerability to lipopolysaccharide. Respir. Physiol. Neurobiol. 232, 26–34 (2016).

    Article  CAS  PubMed  Google Scholar 

  15. Qu, D. et al. Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance. Pediatr. Res. 93, 1239–1249 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  16. MacFarlane, P. M., Mayer, C. A. & Litvin, D. G. Microglia modulate brainstem serotonergic expression following neonatal sustained hypoxia exposure: implications for sudden infant death syndrome. J. Physiol. 594, 3079–3094 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mayer, C. A., Di Fiore, J. M., Martin, R. J. & Macfarlane, P. M. Vulnerability of neonatal respiratory neural control to sustained hypoxia during a uniquely sensitive window of development. J. Appl Physiol. 116, 514–521 (1985).

    Article  Google Scholar 

  18. Young, J. O., Geurts, A., Hodges, M. R. & Cummings, K. J. Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin. J. Appl Physiol. 123, 825–834 (1985).

    Article  Google Scholar 

  19. Haynes R. L. Biomarkers of Sudden Infant Death Syndrome (SIDS) Risk and SIDS Death. In SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future Chapter 32. (Adelaide (AU), University of Adelaide Press, 2018).

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William and Lois Briggs Research Endowment.

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Correspondence to Peter M. MacFarlane.

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MacFarlane, P.M. Inflammation in sudden infant death syndrome. Pediatr Res 95, 885–886 (2024). https://doi.org/10.1038/s41390-023-02966-8

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