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Leveraging aggression risk gene expression in the developing and adult human brain to guide future precision interventions

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Fig. 1: Aggression risk gene brain region enrichment and developmental regulation.

References

  1. Kanne SM, Mazurek MO. Aggression in children and adolescents with ASD: prevalence and risk factors. J Autism Dev Disord. 2011;41:926–37.

    Article  Google Scholar 

  2. Saylor KE, Amann BH. Impulsive aggression as a comorbidity of attention-deficit/hyperactivity disorder in children and adolescents. J Child Adolesc Psychopharmacol. 2016;26:19–25.

    Article  Google Scholar 

  3. Zhang-James Y, Fernàndez-Castillo N, Hess JL, Malki K, Glatt SJ, Cormand B, et al. An integrated analysis of genes and functional pathways for aggression in human and rodent models. Mol Psychiatry. 2019;24:1655–67. https://doi.org/10.1038/s41380-018-0068-7.

    Article  CAS  PubMed  Google Scholar 

  4. Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, et al. Transcriptional landscape of the prenatal human brain. Nature. 2014;508:199–206.

    Article  CAS  Google Scholar 

  5. Dougherty JD, Schmidt EF, Nakajima M, Heintz N. Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 2010;38:4218–30.

    Article  CAS  Google Scholar 

  6. Specific Expression Analysis (SEA). http://genetics.wustl.edu/jdlab/csea-tool-2/. Accessed 4 July 2020.

  7. Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell. 2013;155:997–1007.

    Article  CAS  Google Scholar 

  8. Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, et al. Reduced amygdala-prefrontal functional connectivity in children with autism spectrum disorder and co-occurring disruptive behavior. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019;4:1031–41.

    PubMed  PubMed Central  Google Scholar 

  9. Hoptman MJ. Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment. CNS Spectr. 2015;20:280–6.

    Article  Google Scholar 

  10. Jackman SL, Chen CH, Offermann HL, Drew IR, Harrison BM, Bowman AM, et al. Cerebellar Purkinje cell activity modulates aggressive behavior. Elife. 2020;9:e53229.

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by National Institutes of Health grants K23MH116339 (ASL) and R01MH114927 (TVF).

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Authors and Affiliations

  1. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Ahra Kim & Simon N. Vandekar

  2. Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Sarah L. Rader & Alan S. Lewis

  3. Yale Child Study Center, Yale School of Medicine, New Haven, CT, 06520, USA

    Thomas V. Fernandez

  4. Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Alan S. Lewis

  5. Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, 37212, USA

    Alan S. Lewis

  6. Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA

    Alan S. Lewis

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  1. Ahra Kim
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  2. Sarah L. Rader
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  3. Thomas V. Fernandez
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  4. Simon N. Vandekar
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Correspondence to Alan S. Lewis.

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Kim, A., Rader, S.L., Fernandez, T.V. et al. Leveraging aggression risk gene expression in the developing and adult human brain to guide future precision interventions. Mol Psychiatry 26, 2680–2682 (2021). https://doi.org/10.1038/s41380-020-00903-3

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