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Acute myeloid leukemia

SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia

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References

  1. Bochtler T, Frohling S, Krämer A. Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia. Leukemia. 2015;29:1243–52.

    Article  CAS  Google Scholar 

  2. Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424–47.

    Article  Google Scholar 

  3. Laurie CC, Laurie CA, Rice K, Doheny KF, Zelnick LR, McHugh CP, et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet. 2012;44:642–50.

    Article  CAS  Google Scholar 

  4. Jessberger R. Age-related aneuploidy through cohesion exhaustion. EMBO Rep. 2012;13:539–46.

    Article  CAS  Google Scholar 

  5. Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet. 2013;45:1232–7.

    Article  CAS  Google Scholar 

  6. Thota S, Viny AD, Makishima H, Spitzer B, Radivoyevitch T, Przychodzen B, et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood. 2014;124:1790–8.

    Article  CAS  Google Scholar 

  7. Fisher JB, McNulty M, Burke MJ, Crispino JD, Rao S. Cohesin Mutations in Myeloid Malignancies. Trends Cancer. 2017;3:282–93.

    Article  CAS  Google Scholar 

  8. Remeseiro S, Cuadrado A, Carretero M, Martinez P, Drosopoulos WC, Canamero M, et al. Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J. 2012;31:2076–89.

    Article  CAS  Google Scholar 

  9. Cuadrado A, Remeseiro S, Gomez-Lopez G, Pisano DG, Losada A. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle. 2012;11:2233–8.

    Article  CAS  Google Scholar 

  10. Viny AD, Ott CJ, Spitzer B, Rivas M, Meydan C, Papalexi E, et al. Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis. J Exp Med. 2015;212:1819–32.

    Article  CAS  Google Scholar 

  11. Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, et al. Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications. Blood. 2014;123:914–20.

    Article  CAS  Google Scholar 

  12. Losada A. Cohesin in cancer: chromosome segregation and beyond. Nat Rev Cancer. 2014;14:389–93.

    Article  CAS  Google Scholar 

  13. Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci USA. 2008;105:3443–8.

    Article  CAS  Google Scholar 

  14. Carvalhal S, Tavares A, Santos MB, Mirkovic M, Oliveira RA. A quantitative analysis of cohesin decay in mitotic fidelity. J Cell Biol. 2018; https://doi.org/10.1083/jcb.201801111 [Epub ahead of print].

    Article  CAS  Google Scholar 

  15. Heidinger-Pauli JM, Mert O, Davenport C, Guacci V, Koshland D. Systematic reduction of cohesin differentially affects chromosome segregation, condensation, and DNA repair. Curr Biol. 2010;20:957–63.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by Deutsche Forschungsgemeinschaft (DFG) and Wilhelm Sander-Stiftung.

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Authors and Affiliations

  1. Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany

    Bianca Kraft, Jan Lombard, Michael Kirsch & Alwin Krämer

  2. Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg, German Red Cross Blood Service Baden-Wuerttemberg—Hessen, Mannheim, Germany

    Patrick Wuchter & Peter Bugert

  3. Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Thomas Hielscher

  4. Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany

    Norbert Blank & Alwin Krämer

Authors
  1. Bianca Kraft
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  2. Jan Lombard
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  3. Michael Kirsch
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  4. Patrick Wuchter
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  5. Peter Bugert
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  6. Thomas Hielscher
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  7. Norbert Blank
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  8. Alwin Krämer
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Correspondence to Alwin Krämer.

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Kraft, B., Lombard, J., Kirsch, M. et al. SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia. Leukemia 33, 795–799 (2019). https://doi.org/10.1038/s41375-018-0287-6

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