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Chronic myeloproliferative neoplasms

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses

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Acknowledgements

We are grateful to Dr. Bruce Beutler for advice to use TNFα inhibitor, adalimumab.

Author contributions

JP conceived and designed this study; TT collected and analyzed the data and drafted the manuscript; SS conceived TNFα studies and with SJK and JS performed the molecular analyses; KK isolated CD34+ cells from the marrows, MS and NH analyzed cytokines, KH and SL secured IRB compliance. All authors approved the manuscript.

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Authors and Affiliations

  1. Division of Hematology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Tsewang Tashi, Sabina Swierczek, Soo Jin Kim, Jihyun Song, Kim Hickman, Scott Litton & Josef T. Prchal

  2. Department of Pathology, ARUP Institute of Research and Development, University of Utah School of Medicine, Salt Lake City, UT, USA

    Mohamed E. Salama, Nahla Heikal & Josef T. Prchal

  3. Department of Pediatric Infectious Diseases and Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA

    Katherine Y. King

Authors
  1. Tsewang Tashi
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  2. Sabina Swierczek
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  3. Soo Jin Kim
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  4. Mohamed E. Salama
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  5. Jihyun Song
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  6. Nahla Heikal
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  7. Katherine Y. King
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  8. Kim Hickman
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  9. Scott Litton
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  10. Josef T. Prchal
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Corresponding author

Correspondence to Josef T. Prchal.

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The authors declare that they have no conflict of interest.

Additional information

These authors contributed equally: Tsewang Tashi, Sabina Swierczek, Soo Jin Kim.

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Tashi, T., Swierczek, S., Kim, S.J. et al. Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses. Leukemia 32, 1830–1833 (2018). https://doi.org/10.1038/s41375-018-0080-6

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