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Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

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Authors and Affiliations

  1. Cytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Frederick, MD, USA

    Sarah D. Cramer, Julie A. Hixon, Caroline Andrews, Ross J. Porter, Gisele O. L. Rodrigues, Tim Back, Kelli Czarra, Emilee Senkevitch, Wenqing Li & Scott K. Durum

  2. Department of Veterinary Medicine, University of Maryland, College Park, MD, USA

    Sarah D. Cramer

  3. Molecular Biology Laboratory, Boldrini Children’s Center, Campinas, Brazil

    Gisele O. L. Rodrigues

  4. Department of Genetics, Evolution and Bioagents, Institute of Biology, State University of Campinas, Campinas, Brazil

    Gisele O. L. Rodrigues

  5. Genomics Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc. (LBR), Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA

    Xiaolin Wu

  6. Laboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, MD, USA

    Helen Michael

  7. Center for Cancer Research Collaborative Bioinformatics Resource, NCI, NIH, Bethesda, MD, USA

    Maggie Cam & Jack Chen

  8. Protein Expression Laboratory/RAS Reagents Core, NCI RAS Initiative, LBR, FNLCR, Frederick, MD, USA

    Dominic Esposito

  9. Leukemia Biology Section, Genetics Branch, NCI, NIH, Bethesda, MD, USA

    Vijay Negi & Peter D. Aplan

  10. School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, Scotland, UK

    Ross J. Porter

Authors
  1. Sarah D. Cramer
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  2. Julie A. Hixon
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  3. Caroline Andrews
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  5. Gisele O. L. Rodrigues
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  7. Tim Back
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  8. Kelli Czarra
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  9. Helen Michael
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  10. Maggie Cam
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  11. Jack Chen
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  12. Dominic Esposito
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  13. Emilee Senkevitch
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  14. Vijay Negi
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  15. Peter D. Aplan
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  16. Wenqing Li
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  17. Scott K. Durum
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Corresponding author

Correspondence to Scott K. Durum.

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Conflict of interest

S.K.D., W.L, and J.A.H. have applied for a patent titled “IL-7Rα antibodies for treating acute lymphoblastic leukemia.” (US patent application #62/238 612)

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Cramer, S.D., Hixon, J.A., Andrews, C. et al. Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia. Leukemia 32, 1795–1882 (2018). https://doi.org/10.1038/s41375-017-0001-0

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  • DOI: https://doi.org/10.1038/s41375-017-0001-0

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