Skip to main content

Advertisement

SpringerLink
Log in

Interleukin-6 induces increased motility, cell–cell and cell–substrate dyshesion and epithelial-to-mesenchymal transformation in breast cancer cells

  • Letter to the Editor
  • Published:
Oncogene Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bromberg J, Wang TC . (2009). Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 15: 17–80.

    Article  Google Scholar 

  • Chen L, Mory Y, Zilberstein A, Revel M . (1988). Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-β2 . Proc Natl Acad Sci USA 85: 8037–8041.

    Article  CAS  PubMed  Google Scholar 

  • Chen L, Shulman LM, Revel M . (1991). IL-6 receptors and sensitivity to growth inhibition by IL-6 in clones of human breast carcinoma cells. J Biol Regul Homeostat Agents 5: 125–136.

    CAS  Google Scholar 

  • Chiu JJ, Sgagias MK, Cowan KH . (1996). Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines. Clin Cancer Res 2: 215–221.

    CAS  PubMed  Google Scholar 

  • Choppin PW . (2007). A Biographical Memoir of Igor Tamm (1922-1995). National Academy of Sciences USA: Washington, DC, pp 1–17.

    Google Scholar 

  • Krueger J, Ray A, Tamm I, Sehgal PB . (1991). Expression and function of interleukin-6 in epithelial cells. J Cell Biochem 45: 327–334.

    Article  CAS  PubMed  Google Scholar 

  • Margulies L, Sehgal PB . (1993). Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPβ (NF-IL6) activity by p53 species. J Biol Chem 268: 15096–15100.

    CAS  PubMed  Google Scholar 

  • Sehgal PB . (1990). Interleukin 6 in infection and cancer. Proc Soc Exp Biol Med 195: 183–191.

    Article  CAS  PubMed  Google Scholar 

  • Sehgal PB . (1998). Cytokines in the host-tumor interaction. In: Mackiewicz A, Sehgal PB (eds). Molecular Aspects of Cancer and Its Therapy. Birkhauser Verlag: Basel, pp 89–106.

    Chapter  Google Scholar 

  • Sehgal PB, Tamm I . (1991). Interleukin-6 enhances motility of breast carcinoma cells. In: Goldberg ID (ed). Cell Motility Factors. Birkhauser Verlag: Basel–Boston–Berlin, pp 178–193.

    Chapter  Google Scholar 

  • Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N et al. (2009). Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28: 2940–2947.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tabibzadeh SS, Poubouridis D, May LT, Sehgal PB . (1989). Interleukin-6 immunoreactivity in human tumors. Am J Pathol 135: 427–433.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB . (1989). Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells. J Exp Med 170: 1649–1669.

    Article  CAS  PubMed  Google Scholar 

  • Tamm I, Cardinale I, Murphy JS . (1991a). Decreased adherence of interleukin 6-treated breast carcinoma cells can lead to separation from neighbors after mitosis. Proc Natl Acad Sci USA 88: 4414–4418.

    Article  CAS  PubMed  Google Scholar 

  • Tamm I, Cardinale I, Sehgal PB . (1991b). Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells. Cytokine 3: 212–223.

    Article  CAS  PubMed  Google Scholar 

  • Tamm I, Cardinale I, Kikuchi T, Krueger JG . (1994a). E-cadherin distribution in interleukin-6-induced cell-cell separation of ductal breast carcinoma cells. Proc Natl Acad Sci USA 91: 4338–4342.

    Article  CAS  PubMed  Google Scholar 

  • Tamm I, Kikuchi T, Cardinale I, Krueger JG . (1994b). Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells. Proc Natl Acad Sci USA 91: 3329–3333.

    Article  CAS  PubMed  Google Scholar 

  • Tamm I, Kikuchi T, Cardinale I, Murphy JS, Krueger JG . (1998). Cytokines in breast cancer cell dyshesion. In: Mackiewicz A, Sehgal PB (eds). Molecular Aspects of Cancer and Its Therapy. Birkhauser Verlag: Basel, pp 89–106.

    Google Scholar 

  • Walter M, Liang S, Ghosh S, Hornsby PJ, Li R . (2009). Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 28: 2745–2755.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Cell Biology & Anatomy, and Medicine, New York Medical College, Valhalla, NY, USA

    P B Sehgal

Authors
  1. P B Sehgal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P B Sehgal.

Ethics declarations

Competing interests

Dr Sehgal's work has been funded by the NIH.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sehgal, P. Interleukin-6 induces increased motility, cell–cell and cell–substrate dyshesion and epithelial-to-mesenchymal transformation in breast cancer cells. Oncogene 29, 2599–2600 (2010). https://doi.org/10.1038/onc.2010.4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/onc.2010.4

  • Springer Nature Limited

This article is cited by

Search

Navigation