Chromosome end protection is accomplished by telomeres. How cells cope with spontaneously unprotected telomeres while avoiding cell cycle arrest or cell death is a fascinating question.
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Karlseder, J. Chromosome end protection becomes even more complex. Nat Struct Mol Biol 16, 1205–1206 (2009). https://doi.org/10.1038/nsmb1209-1205
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DOI: https://doi.org/10.1038/nsmb1209-1205
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