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TIRF(ing) reveals Msh2-Msh6 surfing on DNA

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Faced with the thermodynamic and kinetic challenge of finding a few specific sites on DNA among millions of nonspecific sites, within a limited amount of time, what's a protein to do? Single-molecule studies show that some proteins have selected sliding on DNA as a solution.

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Figure 1: A model depicting Msh2-Msh6 movement on DNA.

Katie Ris-Vicari

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Authors and Affiliations

  1. Manju M. Hingorani is in the Molecular Biology and Biochemistry Department, Wesleyan University, Middletown, Connecticut 06459, USA. mhingorani@wesleyan.edu,

    Manju M Hingorani

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  1. Manju M Hingorani
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Hingorani, M. TIRF(ing) reveals Msh2-Msh6 surfing on DNA. Nat Struct Mol Biol 14, 1124–1125 (2007). https://doi.org/10.1038/nsmb1207-1124

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