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Rhomboid intramembrane protease structures galore!

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The first structures of an intramembrane serine protease reveal a catalytic His-Ser dyad in a water-filled cavity surrounded by six transmembrane helices, but just how substrate helices gain access to the dyad is controversial.

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Figure 1: Structures of GlpG rhomboid intramembrane serine proteases from E. coli.

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Acknowledgements

This work was supported in part by grants from the National Institute of General Medical Sciences and the National Center for Research Resources, US National Institutes of Health.

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  1. the Department of Physiology and Biophysics, University of California at Irvine, Irvine, 92697-4560, California, USA

    Stephen H White

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  1. Stephen H White
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White, S. Rhomboid intramembrane protease structures galore!. Nat Struct Mol Biol 13, 1049–1051 (2006). https://doi.org/10.1038/nsmb1206-1049

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