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Lighting up nucleosome spacing

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The mechanism by which ATP-dependent remodeling enzymes act to space nucleosomes is as yet unclear. A new study uses FRET to monitor nucleosome repositioning in real time to address how these enzymes sense when nucleosomes are evenly distributed.

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Figure 1: Possible roles for nucleosome spacing in gene regulation under conditions of different nucleosome spacing.
Figure 2: Mechanisms for nucleosome spacing.

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Authors and Affiliations

  1. the Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK

    Helder Ferreira & Tom Owen-Hughes

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  1. Helder Ferreira
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  2. Tom Owen-Hughes
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Ferreira, H., Owen-Hughes, T. Lighting up nucleosome spacing. Nat Struct Mol Biol 13, 1047–1049 (2006). https://doi.org/10.1038/nsmb1206-1047

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