Skip to main content
Log in

Two Ps in the bacterial pod

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

RNase P is an ancient ribonucleoprotein (RNP) enzyme present in every living organism. Several recent reports collectively provide a structural and functional analysis of this 'simple' RNP and result in a better understanding of the apparent differences between the two types of RNase P in bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Structural comparison of bacterial RNase Ps.
Figure 2: Model of the RNase P holoenzyme.

References

  1. Altman, S. & Kirsebom, L. Ribonuclease P. in The RNA World 2nd edn (eds. Gesteland, R.F., Cech, T.R. & Atkins, J.F.) 351–380 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 1999).

    Google Scholar 

  2. Frank, D.N. & Pace, N.R. Annu. Rev. Biochem. 67, 153–180 (1998).

    CAS  PubMed  Google Scholar 

  3. Hartmann, E. & Hartmann, R.K. Trends Genet. 19, 561–569 (2003).

    CAS  PubMed  Google Scholar 

  4. Xiao, S., Day-Storms, J.J., Srisawat, C., Fierke, C.A. & Engelke, D.R. RNA 11, 885–896 (2005).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Xiao, S., Scott, F., Fierke, C.A. & Engelke, D.R. Annu. Rev. Biochem. 71, 165–189 (2002).

    CAS  PubMed  Google Scholar 

  6. Kazantsev, A.V. et al. Proc. Natl. Acad. Sci. USA 102, 13392–13397 (2005).

    CAS  Google Scholar 

  7. Torres-Larios, A., Swinger, K.K., Krasilnikov, A.S., Pan, T. & Mondragon, A. Nature 437, 584–587 (2005).

    CAS  PubMed  Google Scholar 

  8. Buck, A.H., Dalby, A.B., Poole, A.W., Kazantsev, A.V. & Pace, N.R. EMBO J. published online 15 September 2005 (10.1038/sj.emboj.7600805).

  9. Buck, A.H., Kazantsev, A.V., Dalby, A.B. & Pace, N.R. Nat. Struct. Mol. Biol. 12, 958–964 (2005).

    CAS  PubMed  Google Scholar 

  10. Loria, A. & Pan, T. RNA 2, 551–563 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Pan, T. Biochemistry 34, 902–909 (1995).

    CAS  PubMed  Google Scholar 

  12. Fang, X.W. et al. RNA 7, 233–241 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Harris, M.E. et al. EMBO J. 13, 3953–3963 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Niranjanakumari, S., Kurz, J.C. & Fierke, C.A. Nucleic Acids Res. 26, 3090–3096 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Biswas, R., Ledman, D.W., Fox, R.O., Altman, S. & Gopalan, V. J. Mol. Biol. 296, 19–31 (2000).

    CAS  PubMed  Google Scholar 

  16. Loria, A., Niranjanakumari, S., Fierke, C.A. & Pan, T. Biochemistry 37, 15466–15473 (1998).

    CAS  PubMed  Google Scholar 

  17. Rox, C., Feltens, R., Pfeiffer, T. & Hartmann, R.K. J. Mol. Biol. 315, 551–560 (2002).

    CAS  PubMed  Google Scholar 

  18. Tsai, H.Y., Masquida, B., Biswas, R., Westhof, E. & Gopalan, V. J. Mol. Biol. 325, 661–675 (2003).

    CAS  PubMed  Google Scholar 

  19. Reich, C., Olsen, G.J., Pace, B. & Pace, N.R. Science 239, 178–181 (1988).

    CAS  PubMed  Google Scholar 

  20. Tallsjo, A. & Kirsebom, L.A. Nucleic Acids Res. 21, 51–57 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Kurz, J.C., Niranjanakumari, S. & Fierke, C.A. Biochemistry 37, 2393–2400 (1998).

    CAS  PubMed  Google Scholar 

  22. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. & Altman, S. Cell 35, 849–857 (1983).

    CAS  PubMed  Google Scholar 

  23. Waugh, D.S. & Pace, N.R. J. Bacteriol. 172, 6316–6322 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Stams, T., Niranjanakumari, S., Fierke, C.A. & Christianson, D.W. Science 280, 752–755 (1998).

    CAS  PubMed  Google Scholar 

  25. Spitzfaden, C. et al. J. Mol. Biol. 295, 105–115 (2000).

    CAS  PubMed  Google Scholar 

  26. Kazantsev, A.V. et al. Proc. Natl. Acad. Sci. USA 100, 7497–7502 (2003).

    CAS  PubMed  Google Scholar 

  27. Loria, A. & Pan, T. Nucleic Acids Res. 29, 1892–1897 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Westhof, E., Wesolowski, D. & Altman, S. J. Mol. Biol. 258, 600–613 (1996).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peculis, B. Two Ps in the bacterial pod. Nat Struct Mol Biol 12, 941–943 (2005). https://doi.org/10.1038/nsmb1105-941

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb1105-941

  • Springer Nature America, Inc.

Navigation