Skip to main content
SpringerLink
Log in

Sensing of DNA damage by XPC/Rad4: one protein for many lesions

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Through its crucial role in DNA damage recognition and initiation of nucleotide excision repair in mammals, XPC protein represents a first line of defense against carcinogenesis. The recent elucidation of the molecular structure of the yeast XPC homolog Rad4 provides new insights into how eukaryotic cells recognize structurally diverse DNA lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Model for DNA damage recognition by XPC or its homolog Rad4.

References

  1. Friedberg, E.C. Nat. Rev. Cancer 1, 22–33 (2001).

    Article  CAS  Google Scholar 

  2. Riedl, T., Hanaoka, F. & Egly, J.-M. EMBO J. 22, 5293–5303 (2003).

    Article  CAS  Google Scholar 

  3. Sugasawa, K. et al. Mol. Cell 2, 223–232 (1998).

    Article  CAS  Google Scholar 

  4. Volker, M. et al. Mol. Cell 8, 213–224 (2001).

    Article  CAS  Google Scholar 

  5. Mol, C.D., Parikh, S.S., Putnam, C.D., Lo, T.P. & Tainer, J.A. Annu. Rev. Biophys. Biomol. Struct. 28, 101–128 (1999).

    Article  CAS  Google Scholar 

  6. Min, J.-H. & Pavletich, N.P. Nature, published online 19 September 2007 (doi:10.1038/nature06155). (2007).

    Google Scholar 

  7. Anantharaman, V., Koonin, E.V. & Aravind, L. Hum. Mol. Genet. 10, 1627–1630 (2001).

    Article  CAS  Google Scholar 

  8. Ikegami, T. et al. Nat. Struct. Biol. 5, 701–706 (1998).

    Article  CAS  Google Scholar 

  9. Sugasawa, K., Shimizu, Y., Iwai, S. & Hanaoka, F. DNA Repair (Amst.) 1, 95–107 (2002).

    Article  CAS  Google Scholar 

  10. Janicijevic, A. et al. DNA Repair (Amst.) 2, 325–336 (2003).

    Article  CAS  Google Scholar 

  11. Batty, D., Rapic-Otrin, V., Levine, A.S. & Wood, R.D. J. Mol. Biol. 300, 275–290 (2000).

    Article  CAS  Google Scholar 

  12. Sugasawa, K. et al. Cell 121, 387–400 (2005).

    Article  CAS  Google Scholar 

  13. El-Mahdy, M.A. et al. J. Biol. Chem. 281, 13404–13411 (2006).

    Article  CAS  Google Scholar 

  14. Fitch, M.E., Nakajima, S., Yasui, A. & Ford, J.M. J. Biol. Chem. 278, 46906–46910 (2003).

    Article  CAS  Google Scholar 

  15. Moser, J. et al. DNA Repair (Amst.) 4, 571–582 (2005).

    Article  CAS  Google Scholar 

  16. Wang, Q.E., Zhu, Q., Wani, G., Chen, J. & Wani, A.A. Carcinogenesis 25, 1033–1043 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kaoru Sugasawa is at the Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Nada-ku, Kobe 657-8501, Japan. ksugasawa@garnet.kobe-u.ac.jp,

    Kaoru Sugasawa

  2. Fumio Hanaoka is at the Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan. fhanaoka@fbs.osaka-u.ac.jp,

    Fumio Hanaoka

Authors
  1. Kaoru Sugasawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fumio Hanaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sugasawa, K., Hanaoka, F. Sensing of DNA damage by XPC/Rad4: one protein for many lesions. Nat Struct Mol Biol 14, 887–888 (2007). https://doi.org/10.1038/nsmb1007-887

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb1007-887

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation