Telomeres are crucial for maintaining the integrity of the genome. Several alternative structures have been proposed for these caps, and understanding their biological significance is a matter of great interest. Probing of native telomeres now reveals that telomere end-binding proteins may control the formation of G-quadruplex DNA in vivo.
References
Cech, T.R. Cell 116, 273–279 (2004).
Smogorzewska, A. & de Lange, T. Annu. Rev. Biochem. 73, 177–208 (2004).
Gottschling, D.E. & Zakian, V.A. Cell 47, 195–205 (1986).
Price, C.M. & Cech, T.R. Genes Dev. 1, 783–793 (1987).
Paeschke, K., Simonsson, T., Postberg, J., Rhodes, D. & Lipps, H.J. Nat. Struct. Mol. Biol. 12, 847–854 (2005).
Horvath, M.P., Schweiker, V.L., Bevilacqua, J.M., Ruggles, J.A. & Schultz, S.C. Cell 95, 963–974 (1998).
Froelich-Ammon, S.J., Dickinson, B.A., Bevilacqua, J.M., Schultz, S.C. & Cech, T.R. Genes Dev. 12, 1504–1514 (1998).
Jonsson, F., Postberg, J., Schaffitzel, C. & Lipps, H.J. Chromosome Res. 10, 445–453 (2002).
Garvik, B., Carson, M. & Hartwell, L. Mol. Cell. Biol. 15, 6128–6138 (1995).
Baumann, P. & Cech, T.R. Science 292, 1171–1175 (2001).
Hockemeyer, D., Sfeir, A.J., Shay, J.W., Wright, W.E. & de Lange, T. EMBO J. 24, 2667–2678 (2005).
Veldman, T., Etheridge, K.T. & Counter, C.M. Curr. Biol. 14, 2264–2270 (2004).
Yang, Q., Zheng, Y.L. & Harris, C.C. Mol. Cell. Biol. 25, 1070–1080 (2005).
Schaffitzel, C. et al. Proc. Natl. Acad. Sci. USA 98, 8572–8577 (2001).
Fang, G. & Cech, T.R. Cell 74, 875–885 (1993).
Fang, G., Gray, J.T. & Cech, T.R. Genes Dev. 7, 870–882 (1993).
Postberg, J. et al. J. Cell Sci. 114, 1861–1866 (2001).
Hicke, B. et al. Nucleic Acids Res. 23, 1887–1893 (1995).
Mohaghegh, P., Karow, J.K., Brosh, R.M. Jr., Bohr, V.A. & Hickson, I.D. Nucleic Acids Res. 29, 2843–2849 (2001).
Huber, M.D., Lee, D.C. & Maizels, N. Nucleic Acids Res. 30, 3954–3961 (2002).
Zaug, A.J., Podell, E.R. & Cech, T.R. Proc. Natl. Acad. Sci. USA 102, 10864–10869 (2005).
Gellert, M., Lipsett, M.N. & Davies, D.R. Proc. Natl. Acad. Sci. USA 48, 2013–2018 (1962).
Sundquist, W.I. & Klug, A. Nature 342, 825–829 (1989).
Williamson, J.R., Raghuraman, M.K. & Cech, T.R. Cell 59, 871–880 (1989).
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Baumann, P. Taking control of G-quadruplexes. Nat Struct Mol Biol 12, 832–833 (2005). https://doi.org/10.1038/nsmb1005-832
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DOI: https://doi.org/10.1038/nsmb1005-832
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