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The p53 transcriptional synapse: activation on demand

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The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism.

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Figure 1: Hypothetical model for Cabin1 regulation of p53 activity on the GADD45A gene.

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Authors and Affiliations

  1. Genrich V. Tolstonog and Wolfgang Deppert are at the Heinrich-Pette-Institute for Experimental Virology and Immunology, Martinistr. 52, D-20251 Hamburg, Germany.,

    Genrich V Tolstonog & Wolfgang Deppert

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  1. Genrich V Tolstonog
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  2. Wolfgang Deppert
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Correspondence to Genrich V Tolstonog or Wolfgang Deppert.

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Tolstonog, G., Deppert, W. The p53 transcriptional synapse: activation on demand. Nat Struct Mol Biol 16, 900–901 (2009). https://doi.org/10.1038/nsmb0909-900

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