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A view into the catalytic pocket of cyclic nucleotide phosphodiesterases

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Cyclic nucleotide phosphodiesterases are widely expressed enzymes that function as critical components of cell signaling pathways. In a new study, key interactions in the catalytic pocket essential for substrate selectivity have been identified for these enzymes, thus introducing novel perspectives for drug design.

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Figure 1: Mechanism of substrate recognition in PDEs.

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Authors and Affiliations

  1. Division of Reproductive Biology of the Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, 94305, California, USA

    Marco Conti

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  1. Marco Conti
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Conti, M. A view into the catalytic pocket of cyclic nucleotide phosphodiesterases. Nat Struct Mol Biol 11, 809–810 (2004). https://doi.org/10.1038/nsmb0904-809

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