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Hit and run: X marks the spot!

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Male fruitflies upregulate transcription of nearly all genes on their single X chromosome to equalize expression with the two X chromosomes in females. A new study shows that the distribution of the histone acetylation mark associated with this upregulation is much broader than that of the MSL complex responsible for depositing this mark.

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Figure 1: (a) The MSL complex recognizes ∼150 sequence-specific chromatin entry sites (CES, black boxes) on the male X chromosome and spreads from these onto a subset of actively transcribed genes (red).

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Authors and Affiliations

  1. Vikki M. Weake and Jerry L. Workman are at the Stowers Institute for Medical Research, Kansas City, Missouri, USA.,

    Vikki M Weake & Jerry L Workman

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  1. Vikki M Weake
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  2. Jerry L Workman
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Correspondence to Jerry L Workman.

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Weake, V., Workman, J. Hit and run: X marks the spot!. Nat Struct Mol Biol 16, 801–803 (2009). https://doi.org/10.1038/nsmb0809-801

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