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Getting a grip on O-acetyl-ADP-ribose

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Members of the sirtuin protein family link gene silencing and heterochromatin formation to NAD+-dependent histone deacetylation. Two papers now implicate O-acetyl-ADP-ribose, the metabolite produced by this reaction, as a small-molecule effector that binds to heterochromatic proteins.

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Figure 1: Sirtuin activity and heterochromatin.

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Hoff, K., Wolberger, C. Getting a grip on O-acetyl-ADP-ribose. Nat Struct Mol Biol 12, 560–561 (2005). https://doi.org/10.1038/nsmb0705-560

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