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Simplifying a complex code

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Methylated lysines are essential components of the network of histone modifications, or 'histone code', that regulates gene expression. Work on the methyltransferase Dot1 shows how modifications on different histones interact to modulate activity and how its catalytic mechanism is matched to its role in genome regulation.

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Figure 1: How histone modifications regulate Sir3 binding and Dot1 catalysis.

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Authors and Affiliations

  1. Bryan M. Turner is at the Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk,

    Bryan M Turner

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Turner, B. Simplifying a complex code. Nat Struct Mol Biol 15, 542–544 (2008). https://doi.org/10.1038/nsmb0608-542

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