Skip to main content
SpringerLink
Log in

The human Pol III transcriptome and gene information flow

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

In this issue, three papers report the distribution of the RNA polymerase III (Pol III) machinery, including transcription factor IIIB, transcription factor IIIC and Pol III itself, across the human genome. These studies reveal cell type–specific expression of Pol III genes, functional interplay between the Pol II and Pol III transcriptional machineries and the potential involvement of Pol III genes in chromosome organization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic representation of three typical loci exemplifying cross-regulation of Pol III and Pol II transcription.

References

  1. Paule, M.R. & White, R.J. Nucleic Acids Res. 28, 1283–1298 (2000).

    Article  CAS  Google Scholar 

  2. Raha, D. et al. Proc. Natl. Acad. Sci. USA. 107, 3639–3644 (2010).

    Article  CAS  Google Scholar 

  3. Barski, A. et al. Nat. Struct. Mol. Biol. 17, 629–634 (2010).

    Article  CAS  Google Scholar 

  4. Oler, A.J. et al. Nat. Struct. Mol. Biol. 17, 620–628 (2010).

    Article  CAS  Google Scholar 

  5. Moqtaderi, Z. et al. Nat. Struct. Mol. Biol. 17, 635–640 (2010).

    Article  CAS  Google Scholar 

  6. Dieci, G., Fiorino, G., Castelnuovo, M., Teichmann, M. & Pagano, A. Trends Genet. 23, 614–622 (2007).

    CAS  PubMed  Google Scholar 

  7. Geiduschek, E.P. & Kassavetis, G.A. J. Mol. Biol. 310, 1–26 (2001).

    Article  CAS  Google Scholar 

  8. Moqtaderi, Z. & Struhl, K. Mol. Cell. Biol. 24, 4118–4127 (2004).

    Article  CAS  Google Scholar 

  9. Roberts, D.N., Stewart, A.J., Huff, J.T. & Cairns, B.R. Proc. Natl. Acad. Sci. USA. 100, 14695–14700 (2003).

    Article  CAS  Google Scholar 

  10. Harismendy, O. et al. EMBO J. 22, 4738–4747 (2003).

    Article  CAS  Google Scholar 

  11. Stutz, F., Gouilloud, E. & Clarkson, S.G. Genes Dev. 3, 1190–1198 (1989).

    Article  CAS  Google Scholar 

  12. Fairley, J.A., Scott, P.H. & White, R.J. EMBO J. 22, 5841–5850 (2003).

    Article  CAS  Google Scholar 

  13. Dittmar, K.A., Goodenbour, J.M. & Pan, T. PLoS Genet. 2, e221 (2006).

    Article  Google Scholar 

  14. Listerman, I., Bledau, A.S., Grishina, I. & Neugebauer, K.M. PLoS Genet. 3, e212 (2007).

    Article  Google Scholar 

  15. Mertens, C. & Roeder, R.G. Mol. Cell. Biol. 28, 5764–5776 (2008).

    Article  CAS  Google Scholar 

  16. Gomez-Roman, N. et al. Biochem. Soc. Symp. 73, 141–154 (2006).

    Article  CAS  Google Scholar 

  17. Marshall, L., Kenneth, N.S. & White, R.J. Cell. 133, 78–89 (2008).

    Article  CAS  Google Scholar 

  18. Simms, T.A. et al. Eukaryot. Cell. 7, 2078–2086 (2008).

    Article  CAS  Google Scholar 

  19. Valenzuela, L., Dhillon, N. & Kamakaka, R.T. Genetics. 183, 131–148 (2009).

    Article  CAS  Google Scholar 

  20. Noma, K., Cam, H.P., Maraia, R.J. & Grewal, S.I. Cell. 125, 859–872 (2006).

    Article  CAS  Google Scholar 

  21. Iwasaki, O., Tanaka, A., Tanizawa, H., Grewal, S.I. & Noma, K. Mol. Biol. Cell. 21, 254–265 (2010).

    Article  CAS  Google Scholar 

  22. Scott, K.C., Merrett, S.L. & Willard, H.F. Curr. Biol. 16, 119–129 (2006).

    Article  CAS  Google Scholar 

  23. Donze, D., Adams, C.R., Rine, J. & Kamakaka, R.T. Genes Dev. 13, 698–708 (1999).

    Article  CAS  Google Scholar 

  24. Lunyak, V.V. et al. Science. 317, 248–251 (2007).

    Article  CAS  Google Scholar 

  25. Goodrich, J.A. & Kugel, J.F. Nat. Rev. Mol. Cell Biol. 7, 612–616 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ken-ichi Noma is at The Wistar Institute, Philadelphia, Pennsylvania, USA.,

    Ken-ichi Noma

  2. Rohinton T. Kamakaka is in the Department of Molecular Cell & Developmental Biology, University of California, Santa Cruz, California, USA.,

    Rohinton T Kamakaka

Authors
  1. Ken-ichi Noma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rohinton T Kamakaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ken-ichi Noma or Rohinton T Kamakaka.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Noma, Ki., Kamakaka, R. The human Pol III transcriptome and gene information flow. Nat Struct Mol Biol 17, 539–541 (2010). https://doi.org/10.1038/nsmb0510-539

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0510-539

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation