The yeast proteins Sro7 and Sro77, and their metazoan relatives Lgl and tomosyn, interact with plasma membrane SNARE proteins and control cell polarity. Recently, the crystal structure of yeast Sro7 has been solved, yielding fascinating insights and even more unanswered questions concerning the molecular mechanism of these proteins.
This is a preview of subscription content, log in via an institution to check access.
References
Novick, P. et al. Biochem. Soc. Trans. 34, 683–686 (2006).
Munson, M. & Novick, P. Nat. Struct. Mol. Biol. 13, 577–581 (2006).
Zhang, X. et al. J. Cell Biol. 170, 273–283 (2005).
Lehman, K., Rossi, G., Adamo, J.E. & Brennwald, P. J. Cell Biol. 146, 125–140 (1999).
Hattendorf, D.A., Andreeva, A., Gangar, A., Brennwald, P.J. & Weis, W.I. Nature 446, 567–571 (2007).
Hong, W. Biochim. Biophys. Acta 1744, 493–517 (2005).
Jahn, R. & Scheller, R.H. Nat. Rev. Mol. Cell Biol. 7, 631–643 (2006).
Humbert, P.O., Dow, L.E. & Russell, S.M. Trends Cell Biol. 16, 622–630 (2006).
Wirtz-Peitz, F. & Knoblich, J.A. Trends Cell Biol. 16, 234–241 (2006).
Larsson, K. et al. J. Biol. Chem. 273, 33610–33618 (1998).
Fujita, Y. et al. Neuron 20, 905–915 (1998).
Musch, A. et al. Mol. Biol. Cell 13, 158–168 (2002).
Voegtli, W.C., Madrona, A.Y. & Wilson, D.K. J. Biol. Chem. 278, 34373–34379 (2003).
Mohri, K., Vorobiev, S., Fedorov, A.A., Almo, S.C. & Ono, S. J. Biol. Chem. 279, 31697–31707 (2004).
Appleton, B.A., Wu, P. & Wiesmann, C. Structure 14, 87–96 (2006).
Napetschnig, J., Blobel, G. & Hoelz, A. Proc. Natl. Acad. Sci. USA 104, 1783–1788 (2007).
Brennwald, P. et al. Cell 79, 245–258 (1994).
Pobbati, A.V., Razeto, A., Boddener, M., Becker, S. & Fasshauer, D. J. Biol. Chem. 279, 47192–47200 (2004).
Masuda, E.S., Huang, B.C., Fisher, J.M., Luo, Y. & Scheller, R.H. Neuron 21, 479–480 (1998).
Fasshauer, D., Sutton, R.B., Brünger, A.T. & Jahn, R. Proc. Natl. Acad. Sci. USA 95, 15781–15786 (1998).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Fasshauer, D., Jahn, R. Budding insights on cell polarity. Nat Struct Mol Biol 14, 360–362 (2007). https://doi.org/10.1038/nsmb0507-360
Issue Date:
DOI: https://doi.org/10.1038/nsmb0507-360
- Springer Nature America, Inc.
This article is cited by
-
Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi
BMC Evolutionary Biology (2009)