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A tipping point for mistranslation and disease

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Two papers present strong evidence that the codon-anticodon interaction is poised on a tipping point so that, given a nudge, the tRNA can insert the wrong amino acid into the growing polypeptide chain, leading to translational fidelity loss.

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Figure 1: A 32-38 pair in tRNAAlaGGC for translation fidelity.

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Acknowledgements

We thank C. Florentz and S. Kelley for helpful comments on human mitochondrial tRNAs.

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Authors and Affiliations

  1. Paul Schimmel and Min Guo are at The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, La Jolla, California,USA. schimmel@scripps.edu,

    Paul Schimmel & Min Guo

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  1. Paul Schimmel
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  2. Min Guo
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Schimmel, P., Guo, M. A tipping point for mistranslation and disease. Nat Struct Mol Biol 16, 348–349 (2009). https://doi.org/10.1038/nsmb0409-348

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