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La sets the tone for telomerase assembly

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The functional assembly of a ciliate telomerase requires ordered RNA conformational changes mediated by a La motif–containing protein. This raises new questions about telomerase biogenesis and the evolutionary origin of the telomerase RNA.

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Figure 1: p65-assisted telomerase RNA folding steps, according to ref.4.
Figure 2: Apparently distinct biogenesis pathways for telomerase RNAs in evolutionarily distant eukaryotes.

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Authors and Affiliations

  1. M. Teresa Teixeira and Eric Gilson are in the Laboratory of Molecular Cell Biology, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, IFR128, 46 Allée d'Italie, 69364 Lyon cedex 07, France. eric.gilson@ens-lyon.fr,

    M Teresa Teixeira & Eric Gilson

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  1. M Teresa Teixeira
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  2. Eric Gilson
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Teixeira, M., Gilson, E. La sets the tone for telomerase assembly. Nat Struct Mol Biol 14, 261–262 (2007). https://doi.org/10.1038/nsmb0407-261

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