Sparked by the discovery of LSD1, the first bona fide histone lysine demethylase, a burst of research has opened a new era in understanding how chromatin is regulated, including the identification of the JmjC domain–containing histone demethylases. Now, several independent studies provide evidence that yeast Yjr119Cp, human JARID1 and Drosophila Lid, all members of the JmjC family, demethylate histone H3 trimethyl-Lys4, a mark of transcriptionally active chromatin.
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Metzger, E., Schüle, R. The expanding world of histone lysine demethylases. Nat Struct Mol Biol 14, 252–254 (2007). https://doi.org/10.1038/nsmb0407-252
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DOI: https://doi.org/10.1038/nsmb0407-252
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