Skip to main content
SpringerLink
Log in

Structures and technology for biologists

  • Commentary
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

Structural genomics efforts are already producing a quarter of all 'new' macromolecular structures (<30% sequence identity to previously solved structures) and are stimulating development of systematic and automated approaches to structure determination. The thousands of new structures likely to be determined and the technologies and infrastructure likely to be developed over the next decade will benefit all biologists.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Stevens, C., Yokoyama, S. & Wilson, I.A. Science 294, 89–92 (2001).

    Article  CAS  Google Scholar 

  2. Burley, S.K. Nat. Struct. Biol. 7, 932–934 (2000).

    Article  CAS  Google Scholar 

  3. Vitkup, D., Melamud, E., Moult, J. & Sander, C. Nat. Struct. Biol. 8, 559–566 (2001).

    Article  CAS  Google Scholar 

  4. Terwilliger, T.C. et al. Protein Sci. 9, 1851–1856 (1998).

    Article  Google Scholar 

  5. Harrison, S.C. Nat. Struct. Mol. Biol 11, 13–15 (2004).

    Article  Google Scholar 

  6. Berman, H.M. et al. Nucleic Acids Res. 28, 235–242 (2000).

    Article  CAS  Google Scholar 

  7. Zarembinski, T.I. et al. Proteins 50, 177–183 (2002).

    Article  Google Scholar 

  8. Sutton, G. et al. Structure 12, 341–353 (2004).

    Article  CAS  Google Scholar 

  9. Goulding, C.W. et al. Curr. Drug Targets Infect. Disord. 2, 121–141 (2002).

    Article  CAS  Google Scholar 

  10. Zhang, C. & Kim, S.H. Curr. Opin. Chem. Biol. 7, 28–32 (2003).

    Article  CAS  Google Scholar 

  11. Lim, K. et al. Prot. Struct. Funct. Genet. 45, 397–407 (2001).

    Article  CAS  Google Scholar 

  12. Pieper, U. et al. Nucleic Acids. Res. 30, 255–259 (2002).

    Article  CAS  Google Scholar 

  13. Goh, C.S. et al. J. Mol. Biol. 336, 115–130 (2004).

    Article  CAS  Google Scholar 

  14. Christendat, D. et al. Nat. Struct. Biol. 7, 903–909 (2000).

    Article  CAS  Google Scholar 

  15. Yokoyama, S. Curr. Opin. Chem. Biol. 7, 39–43 (2003).

    Article  CAS  Google Scholar 

  16. Hosfield, D. et al. J. Struct. Biol. 142, 207–217 (2003).

    Article  CAS  Google Scholar 

  17. Hansen, C.L., Skordalakes, E., Berger, J.M. & Quake, S.R. Proc. Natl. Acad. Sci. USA 99, 16531–16536 (2002).

    Article  CAS  Google Scholar 

  18. Abola, E., Kuhn, P., Earnest, T. & Stevens, R.C. Nat. Struct. Biol. 7, 973–977 (2000).

    Article  CAS  Google Scholar 

  19. Lamzin, V.S. & Perrakis, A.R. Nat. Struct. Biol. 7, 978–981 (2000).

    Article  CAS  Google Scholar 

  20. Montelione, G.T., Zheng, D., Huang, Y.J., Gunsalus, K.C. & Szyperski, T. Nat. Struct. Biol. 7, 982–985 (2000).

    Article  CAS  Google Scholar 

  21. Pedelacq, J.D. et al. Nat. Biotechnol. 20, 927–932 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Los Alamos National Laboratory, Los Alamos, 87545, New Mexico, USA

    Thomas C Terwilliger

  2. Mycobacterium tuberculosis Structural Genomics Consortium,

    Thomas C Terwilliger

Authors
  1. Thomas C Terwilliger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Terwilliger, T. Structures and technology for biologists. Nat Struct Mol Biol 11, 296–297 (2004). https://doi.org/10.1038/nsmb0404-296

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0404-296

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation