Skip to main content

Advertisement

SpringerLink
Log in

Glutamate receptor ion channels: where do all the calories go?

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Glutamate receptor ion channels use the free energy of ligand binding to trigger ion channel activation and desensitization. In this issue, an analysis of all-atom molecular dynamics simulations dissects the binding process, reveals a substantial gain in free energy produced by domain closure for agonists and reports unique energy landscapes for individual ligands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Free-energy changes revealed by molecular dynamics simulations for the GluA2 LBD.

References

  1. Traynelis, S.F. et al. Pharmacol. Rev. 62, 405–496 (2010).

    Article  CAS  Google Scholar 

  2. Jin, R., Banke, T.G., Mayer, M.L., Traynelis, S.F. & Gouaux, E. Nat. Neurosci. 6, 803–810 (2003).

    Article  CAS  Google Scholar 

  3. Inanobe, A., Furukawa, H. & Gouaux, E. Neuron 47, 71–84 (2005).

    Article  CAS  Google Scholar 

  4. Lau, A.Y. & Roux, B. Nat. Struct. Mol. Biol. 18, 283–287 (2011).

    Article  CAS  Google Scholar 

  5. Sobolevsky, A.I., Rosconi, M.P. & Gouaux, E. Nature 462, 745–756 (2009).

    Article  CAS  Google Scholar 

  6. Pøhlsgaard, J., Frydenvang, K., Madsen, U. & Kastrup, J.S. Neuropharmacology 60, 135–150 (2011).

    Article  Google Scholar 

  7. Armstrong, N. & Gouaux, E. Neuron 28, 165–181 (2000).

    Article  CAS  Google Scholar 

  8. Sun, Y. et al. Nature 417, 245–253 (2002).

    Article  CAS  Google Scholar 

  9. Horning, M.S. & Mayer, M.L. Neuron 41, 379–388 (2004).

    Article  CAS  Google Scholar 

  10. Weston, M.C., Schuck, P., Ghosal, A., Rosenmund, C. & Mayer, M.L. Nat. Struct. Mol. Biol. 13, 1120–1127 (2006).

    Article  CAS  Google Scholar 

  11. Zhang, W., Cho, Y., Lolis, E. & Howe, J.R. J. Neurosci. 28, 932–943 (2008).

    Article  Google Scholar 

  12. Chaudhry, C., Weston, M.C., Schuck, P., Rosenmund, C. & Mayer, M.L. EMBO J. 28, 1518–1530 (2009).

    Article  CAS  Google Scholar 

  13. Jin, R. et al. J. Neurosci. 25, 9027–9036 (2005).

    Article  CAS  Google Scholar 

  14. Ahmed, A.H., Ptak, C.P. & Oswald, R.E. Biochemistry 49, 2843–2850 (2010).

    Article  CAS  Google Scholar 

  15. Arinaminpathy, Y., Sansom, M.S. & Biggin, P.C. Mol. Pharmacol. 69, 11–18 (2006).

    CAS  PubMed  Google Scholar 

  16. Kaye, S.L., Sansom, M.S. & Biggin, P.C. J. Biol. Chem. 281, 12736–12742 (2006).

    Article  CAS  Google Scholar 

  17. Das, U., Kumar, J., Mayer, M.L. & Plested, A.J. Proc. Natl. Acad. Sci. USA 107, 8463–8468 (2010).

    Article  CAS  Google Scholar 

  18. Menuz, K., Stroud, R.M., Nicoll, R.A. & Hays, F.A. Science 318, 815–817 (2007).

    Article  CAS  Google Scholar 

  19. Mayer, M.L. Neuron 45, 539–552 (2005).

    Article  CAS  Google Scholar 

  20. Hald, H. et al. J. Biol. Chem. 282, 25726–25736 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mark L. Mayer is at the Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.,

    Mark L Mayer

Authors
  1. Mark L Mayer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark L Mayer.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mayer, M. Glutamate receptor ion channels: where do all the calories go?. Nat Struct Mol Biol 18, 253–254 (2011). https://doi.org/10.1038/nsmb0311-253

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0311-253

  • Springer Nature America, Inc.

Search

Navigation